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Articles in Press
11/11/2026 10:11:43 AM | Browse: 9 | Download: 2
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Mechanisms and subcellular rewiring underlying the bidirectional structural remodeling of mitochondria-associated endoplasmic reticulum membranes in liver diseases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Wei Shao, Qin Yang, Jian-Wei Shen, Feng-Tian Wu, Xie Zhang, Feng Xu and Tian-Tian Ge |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Project of NINGBO Leading Medical ＆Health Discipline |
No. 2026-A08 |
| NINGBO Key Clinical Specialty Construction Project |
No. 2024BZZ-1 |
| Ningbo public welfare project |
No. 2024S029 |
| Zhejiang Medical and Health Project |
No. 2025KY206 |
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| Corresponding Author |
Tian-Tian Ge, PhD, Department of Gastroenterology, The Affiliated Lihuili Hospital of Ningbo University, No. 57 Xingning Road, Ningbo 315040, Zhejiang Province, China. gettzju@163.com |
| Key Words |
Mitochondria-associated endoplasmic reticulum membranes; Liver disease; Subcellular signaling; Metabolic dysfunction-associated steatotic liver disease; Bidirectional structural remodeling |
| Core Tip |
Mitochondria-associated endoplasmic reticulum membranes do not follow a single remodeling pattern in liver disease. Depending on disease stage, cell type, and experimental model, mitochondria-associated endoplasmic reticulum membranes may show over-coupling, abnormal dissociation, or adaptive reorganization. This review places these apparently conflicting findings in context by distinguishing structural evidence from functional readouts. Therapeutic strategies should therefore seek to restore a context-appropriate contact state rather than uniformly increase or decrease organelle coupling. |
| Citation |
Shao JW, Yang Q, Shen JW, Wu FT, Zhang X, Xu F, Ge TT. Mechanisms and subcellular rewiring underlying the bidirectional structural remodeling of mitochondria-associated endoplasmic reticulum membranes in liver diseases. World J Gastroenterol 2026; In press
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| PDF |
126097-in-press.pdf
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Received |
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2026-07-24 06:51 |
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Peer-Review Started |
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2026-07-24 06:52 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-27 03:29 |
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Revised |
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2026-09-08 15:32 |
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Publication Fee Transferred |
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2026-11-01 06:43 |
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Second Decision by Editor |
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2026-11-11 06:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-11 10:11 |
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Articles in Press |
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2026-11-11 10:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
