Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	126141
DOI	10.4292/wjgpt.126141
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Autophagy-apoptosis crosstalk in hepatocellular carcinoma: Therapeutic implications of traditional Chinese medicine: A narrative minireview
Manuscript Source	Invited Manuscript
All Author List	Wen-Yan Pan and Xing Liu
Funding Agency and Grant Number
Corresponding Author	Xing Liu, Associate Chief Physician, MD, Department of Emergency, SHENZHEN LONGHUA DISTRACT CENTRAL HOSPITAL, Department of Emergency, Shenzhen Longhua Distract Central Hospital, Shenzhen, Guangdong, 518110, China. Electronic address: liuxing1985@126.com, Shenzhen 518049, Guangdong Province, China. liuxing1985@126.com
Key Words	Hepatocellular carcinoma; Autophagy; Apoptosis; Traditional Chinese medicine; Programmed cell death; Signal transduction; Drug resistance
Core Tip	Hepatocellular carcinoma (HCC) therapy faces drug resistance and limited options. Autophagy and apoptosis are tightly linked, and their balance determines HCC cell fate. This review systematically integrates current evidence on how traditional Chinese medicine (TCM) monomers and formulas coordinately modulate autophagy–apoptosis crosstalk via multi-target signaling networks (e.g., PI3K/AKT/mTOR, Beclin-1, Bcl-2, p53). We evaluate whether TCM might overcome chemoresistance, but conclude that current evidence is insufficient to support this claim; dose-dependent dual effects, experimental heterogeneity, and translational barriers must be addressed in future autophagy-targeted therapeutic strategies.
Citation	Pan WY, Liu X. Autophagy-apoptosis crosstalk in hepatocellular carcinoma: Therapeutic implications of traditional Chinese medicine: A narrative minireview. World J Gastrointest Pharmacol Ther 2026; In press DOI: https://doi.org/10.4292/wjgpt.126141
PDF	126141-in-press.pdf

Received	2026-07-28 07:30
Peer-Review Started	2026-08-05 03:25
First Decision by Editorial Office Director
Return for Revision	2026-10-08 03:23
Revised	2026-10-29 12:41
Publication Fee Transferred
Second Decision by Editor	2026-11-11 06:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-11 10:12
Articles in Press	2026-11-11 10:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com