Publication Name	World Journal of Clinical Cases
Manuscript ID	126184
DOI	10.12998/wjcc.126184
Country	United States

Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	Persistent alpha-fetoprotein elevation in patients without viral hepatitis, cirrhosis, hepatocellular carcinoma: A report of six cases and literature review
Manuscript Source	Unsolicited Manuscript
All Author List	Tung Huynh, Kim Huynh, Joey Zhou and Ke-Qin Hu
Funding Agency and Grant Number
Corresponding Author	Ke-Qin Hu, Director, FAASLD, MD, Professor, Division of Gastroenterology and Hepatology, University of California Irvine, School of Medicine, 101 The City Drive, Building 22C, Room 1503, Orange, CA 92868, United States. kqhu@uci.edu
Key Words	Alpha-fetoprotein; Alpha-fetoprotein elevation; Viral hepatitis; Cirrhosis; Hepatocellular carcinoma; Case report
Core Tip	This case series presents 6 cases of mild, persistent, and stable alpha-fetoprotein elevation in the absence of active liver injury, advanced hepatic fibrosis (or cirrhosis), or neoplasms, with a mean follow-up of 48 months. This is a unique and benign clinical presentation that has not been thoroughly described or previously reported.
Citation	Huynh T, Huynh K, Zhou J, Hu KQ. Persistent alpha-fetoprotein elevation in patients without viral hepatitis, cirrhosis, hepatocellular carcinoma: A report of six cases and literature review. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.126184
PDF	126184-in-press.pdf

Received	2026-07-31 03:28
Peer-Review Started	2026-08-05 03:37
First Decision by Editorial Office Director
Return for Revision	2026-09-09 06:55
Revised	2026-10-02 17:29
Publication Fee Transferred
Second Decision by Editor	2026-10-22 07:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-22 09:03
Articles in Press	2026-10-22 09:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com