Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	126187
DOI	10.4251/wjgo.126187
Country	Thailand

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Toward personalized hepatocellular carcinoma surveillance: A risk-stratified approach
Manuscript Source	Invited Manuscript
All Author List	Huttakan Navadurong, Sombat Treeprasertsuk and Kessarin Thanapirom
Funding Agency and Grant Number
Corresponding Author	Kessarin Thanapirom, Associate Professor, MD, PhD, Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Krung Thep Maha Nakhon, Thailand. kessarin.t@chula.ac.th
Key Words	Hepatocellular carcinoma; Risk stratification; Personalized surveillance; Clinical prediction models; Blood-based biomarkers; Early tumor detection
Core Tip	The conventional one-size-fits-all hepatocellular carcinoma (HCC) surveillance strategy relies on semiannual ultrasound (US) and alpha-fetoprotein testing, an approach that is inadequate for diverse chronic liver disease populations due to low sensitivity in patients with obesity, cirrhosis, or steatosis. To improve early detection, a shift toward personalized surveillance is recommended. This approach uses validated risk stratification models (such as PAGE-B, aMAP, and PLEASE) to determine individual risk. High-risk individuals, or those with poor US visibility, then receive tailored surveillance using multi-analyte blood-based algorithms (such as GALAD and GAAD) or abbreviated magnetic resonance imaging, which may improve early-stage HCC detection and diagnostic accuracy.
Citation	Navadurong H, Treeprasertsuk S, Thanapirom K. Toward personalized hepatocellular carcinoma surveillance: A risk-stratified approach. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.126187
PDF	126187-in-press.pdf

Received	2026-08-03 08:49
Peer-Review Started	2026-08-05 03:33
First Decision by Editorial Office Director
Return for Revision	2026-08-10 08:19
Revised	2026-08-20 03:08
Publication Fee Transferred
Second Decision by Editor	2026-10-28 07:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:23
Articles in Press	2026-10-28 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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