Publication Name	World Journal of Transplantation
Manuscript ID	126281
DOI	10.5500/wjt.126281
Country	Russia

Category	Transplantation
Manuscript Type	Retrospective Cohort Study
Article Title	Exploratory circulating miRNA profile associated with cardiac allograft antibody-mediated rejection: A pilot single-center study
Manuscript Source	Unsolicited Manuscript
All Author List	Daria Kilina, Ekaterina K Zaikova, Lubov Korneva, Maria Osipova, Larisa Vasilieva, Maria Bortsova, Maria Sitnikova, Darina Sambur, Igor Kudryavtsev, Anna Kostareva, Alexey Golovkin, Petr Fedotov and Olga Kalinina
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation 24-15-20016 St. Petersburg Science Foundation 24-15-20016
Corresponding Author	Olga Kalinina, Institute of Molecular Biology and Genetics, Department of Laboratory Medicine with Clinic, Department of Molecular Medicine and Cellular Biology, Almazov National Medical Research Centre, Akkuratova Street 2, Saint Petersburg 197341, Russia. kalinina_ov@almazovcentre.ru
Key Words	Circulating microRNAs; Hsa-miR-193b-5p; Hsa-miR-125b-5p; Hsa-miR-5588-5p; Heart transplantation; Cardiac allograft antibody-mediated rejection; Non-invasive biomarker
Core Tip	Circulating microRNAs (miRNAs) have emerged as promising non-invasive candidate biomarkers for the assessment of transplant injury. The aim of this study was to evaluate circulating miRNA profiles as exploratory candidate biomarkers for detecting rejection in heart transplant (HTx) recipients within the first five years post-transplantation. Plasma samples were collected from 20 HTx recipients with antibody-mediated rejection (AMR), acute cellular rejection, cardiac allograft vasculopathy, and no rejection. Circulating miRNA profiles were generated using next-generation sequencing. Following apeglm shrinkage, hsa-miR-193b-5p, hsa-miR-125b-5p, and hsa-miR-5588-5p were significantly upregulated in recipients with AMR. These preliminary findings require validation in larger independent cohorts before any clinical application.
Citation	Kilina D, Zaikova E, Korneva L, Osipova M, Vasilieva L, Bortsova M, Sitnikova M, Sambur D, Kudryavtsev I, Kostareva A, Golovkin A, Fedotov P, Kalinina O. Exploratory circulating miRNA profile associated with cardiac allograft antibody-mediated rejection: A pilot single-center study. World J Transplant 2026; In press DOI: https://doi.org/10.5500/wjt.126281
PDF	126281-in-press.pdf

Received	2026-08-03 03:25
Peer-Review Started	2026-08-05 03:20
First Decision by Editorial Office Director
Return for Revision	2026-08-14 07:39
Revised	2026-09-07 15:53
Publication Fee Transferred	2026-10-07 09:47
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 03:14
Articles in Press	2026-11-02 03:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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