Publication Name	World Journal of Diabetes
Manuscript ID	126373
DOI	10.4239/wjd.126373
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	CaMKK2 modulates macrophage polarization and is associated with immunometabolic transcriptional changes under high glucose conditions
Manuscript Source	Unsolicited Manuscript
All Author List	Ping Tang, Wei-Chang Guo, He-Jia Yin and Hui-Fang Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82160165 the Famous Doctor Special Program of the Yunnan Xingdian Talent Support Plan RLMY20220009 the Young and Middle-Aged Academic and Technical Leaders Reserve Talent Project of Yunnan Province 202105AC160093
Corresponding Author	Hui-Fang Li, Diabetes, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, Yunnan Province, China. lihf@ydyy.cn
Key Words	Calcium/calmodulin-dependent protein kinase kinase 2; Macrophage polarization; Type 2 diabetes mellitus; Transcriptomics; AKT signaling; High glucose
Core Tip	Under high glucose (HG) conditions, gain- and loss-of-function experiments targeting calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) revealed changes in macrophage polarization-associated markers. Bulk RNA sequencing identified inflammatory and metabolic transcriptional differences between CAMKK2-overexpressing and untransduced cells. CAMKK2 overexpression reduced protein kinase B (AKT) phosphorylation, whereas CAMKK2 knockdown increased it, and the AKT activator SC79 partially attenuated CaMKK2-associated CD86 expression. These findings suggest that CaMKK2 modulates macrophage inflammatory responses under HG conditions, with AKT signaling potentially contributing to the observed effects.
Citation	Tang P, Guo WC, Yin HJ, Li HF. CaMKK2 modulates macrophage polarization and is associated with immunometabolic transcriptional changes under high glucose conditions. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.126373
PDF	126373-in-press.pdf

Received	2026-08-03 08:32
Peer-Review Started	2026-08-05 05:42
First Decision by Editorial Office Director
Return for Revision	2026-09-01 05:56
Revised	2026-09-14 10:23
Publication Fee Transferred	2026-10-15 15:10
Second Decision by Editor	2026-11-06 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-12 10:01
Articles in Press	2026-11-12 10:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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