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Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 126397
Country Singapore
Category Surgery
Manuscript Type Minireviews
Article Title Histotripsy for selected gastrointestinal liver metastases: Current evidence, patient selection and responsible adoption
Manuscript Source Invited Manuscript
All Author List Kai Siang Chan and Vishal G Shelat
Funding Agency and Grant Number
Corresponding Author Vishal G Shelat, Adjunct Associate Professor, Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore. vgshelat@gmail.com
Key Words Colorectal liver metastases; Focused ultrasound; Gastrointestinal cancer; Histotripsy; Liver metastases; Liver-directed therapy; Non-thermal ablation; Surgical oncology
Core Tip Histotripsy is a non-thermal focused-ultrasound therapy with potential value for selected gastrointestinal liver metastases that are visible on ultrasound and accessible through a safe acoustic window. Its likely role is not to replace resection, thermal ablation, stereotactic body radiation therapy, arterial therapy or systemic treatment, but to fill selected local-therapy gaps where heat, needles or radiation are undesirable. Current evidence remains early; responsible adoption requires multidisciplinary selection, standardized imaging follow-up, safety surveillance, registry capture and cost-effectiveness evaluation.
Citation Chan KS, Shelat VG. Histotripsy for selected gastrointestinal liver metastases: Current evidence, patient selection and responsible adoption. World J Gastrointest Pharmacol Ther 2026; In press
Received
2026-08-04 08:16
Peer-Review Started
2026-08-04 08:17
First Decision by Editorial Office Director
Return for Revision
2026-09-02 22:30
Revised
2026-09-13 16:32
Publication Fee Transferred
Second Decision by Editor
2026-11-09 06:26
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-11-09 11:21
Articles in Press
2026-11-09 11:21
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2150-5349 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
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