Publication Name	World Journal of Gastroenterology
Manuscript ID	126421
DOI	10.3748/wjg.126421
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Rifaximin for outcomes beyond hepatic encephalopathy in cirrhosis: An updated systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Eun Jeong Gong and Chang Seok Bang
Funding Agency and Grant Number	Funding Agency Grant Number Hanmi Pharmaceutical Company
Corresponding Author	Chang Seok Bang, MD, PhD, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon Sacred Heart Hospital, Sakju-ro 77, Chuncheon 24253, Gangwon-do, South Korea. cloudslove@naver.com
Key Words	Rifaximin; Cirrhosis; Mortality; Spontaneous bacterial peritonitis; Hepatorenal syndrome; Bacterial infection; Antimicrobial resistance
Core Tip	Rifaximin is guideline-endorsed for preventing recurrent hepatic encephalopathy. Its effect on other outcomes is uncertain because trials differ in indication, comparator, masking and follow-up. The updated mortality pool was significant with conventional inference, but not after small-sample adjustment. Blinded and open-label strata showed no clear difference. Low- and very-low-certainty spontaneous bacterial peritonitis and hepatorenal syndrome signals are hypothesis-generating. Guideline-supported use for recurrent hepatic encephalopathy is unaffected; evidence is insufficient to extend rifaximin routinely to other outcomes.
Citation	Gong EJ, Bang CS. Rifaximin for outcomes beyond hepatic encephalopathy in cirrhosis: An updated systematic review and meta-analysis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.126421
PDF	126421-in-press.pdf

Received	2026-08-04 03:43
Peer-Review Started	2026-08-05 03:16
First Decision by Editorial Office Director
Return for Revision	2026-08-25 02:52
Revised	2026-08-31 06:12
Publication Fee Transferred	2026-09-10 12:41
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:44
Articles in Press	2026-11-04 10:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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