Publication Name	World Journal of Experimental Medicine
Manuscript ID	126492
DOI	10.5493/wjem.126492
Country	China

Category	Virology
Manuscript Type	Opinion Review
Article Title	Self-DNA-induced inflammation and related clinical manifestations: Lessons from coronavirus disease 2019
Manuscript Source	Invited Manuscript
All Author List	Bin Liu
Funding Agency and Grant Number	Funding Agency Grant Number Not applicable NA
Corresponding Author	Bin Liu, Principal Investigator, Professor, Maternal & Child Health Research Institute, Shenzhen Baoan Women’s and Children’s Hospital, No. 56 Yu lv Road, Shenzhen 518102, Guangdong Province, China. liubin7996@dingtalk.com
Key Words	Free deoxyribonucleic acid; Coronavirus disease 2019; Severe cases; Clinical phenotype; Inflammation; Cyclic GMP-AMP synthase-stimulator of interferon genes; Inflammasomes
Core Tip	The interval between peak viral load and severe illness onset in coronavirus disease 2019 (COVID-19) enables investigation of the potential role of self-DNA in severe and sustained inflammation. This view is consistent with many special clinical phenotypes of severe COVID-19. DNA sensor research, particularly on cyclic GMP-AMP synthase, has seen rapid progress. These perspectives may also contribute to future prevention and control of infection of other human-lethal viruses originating from bats, such as Ebola, Marburg, and Hendra viruses.
Citation	Liu B. Self-DNA-induced inflammation and related clinical manifestations: Lessons from coronavirus disease 2019. World J Exp Med 2026; In press DOI: https://doi.org/10.5493/wjem.126492
PDF	126492-in-press.pdf

Received	2026-08-10 02:47
Peer-Review Started	2026-08-10 02:48
First Decision by Editorial Office Director
Return for Revision	2026-09-14 01:39
Revised	2026-09-23 07:49
Publication Fee Transferred
Second Decision by Editor	2026-10-28 07:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:47
Articles in Press	2026-10-28 10:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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