Publication Name	World Journal of Cardiology
Manuscript ID	126612
DOI	10.4330/wjc.126612
Country	Taiwan

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Coenzyme Q10 for heart failure and symptomatic cardiovascular diseases
Manuscript Source	Invited Manuscript
All Author List	Yen-Chen Lin, Wei-Chieh Huang, Chun-Tsai Tsai, Kai-Ti Yang, Yun-Chen Chang, Yen-Po Lin, Wei-Chun Huang and Gen-Min Lin
Funding Agency and Grant Number	Funding Agency Grant Number Hualien Armed Forces General Hospital, Taiwan HAFGH-D-115004
Corresponding Author	Gen-Min Lin, Director, FACC, FAHA, FESC, Department of Medicine, Hualien Armed Forces General Hospital, No. 100 Jinfeng Street, Hualien 970, Taiwan. farmer507@yahoo.com.tw
Key Words	Coenzyme Q10; Heart failure; Ischemic heart disease; Mitochondrial dysfunction; Statins; Microvascular angina
Core Tip	Coenzyme Q10 (CoQ10) plays a dual role in cardiomyocyte bioenergetics and antioxidant defense. In heart failure (HF) and ischemic heart disease, CoQ10 deficiency exacerbates energy starvation and oxidative stress. Evidence from trials like Q-SYMBIO underscores its ability to reduce mortality and hospitalizations in patients with HF with reduced ejection fraction. Additionally, CoQ10 mitigates statin-induced myopathy and cardiomyopathy. Emerging applications in microvascular angina and HF with preserved ejection fraction represent promising frontiers requiring further clinical evaluation.
Citation	Lin YC, Huang WC, Tsai CT, Yang KT, Chang YC, Lin YP, Huang WC, Lin GM. Coenzyme Q10 for heart failure and symptomatic cardiovascular diseases. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.126612
PDF	126612-in-press.pdf

Received	2026-08-10 09:04
Peer-Review Started	2026-08-10 09:04
First Decision by Editorial Office Director
Return for Revision	2026-08-25 07:42
Revised	2026-09-04 16:46
Publication Fee Transferred
Second Decision by Editor	2026-10-28 07:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:26
Articles in Press	2026-10-28 10:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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