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Articles in Press
11/12/2026 10:04:08 AM | Browse: 8 | Download: 2
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Advances in the immunological basis and therapeutic strategies for functional cure of chronic hepatitis B
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fan-E Cheng, Shi-Hao Zheng, Wen-Ying Qi, Xin-Yu Zhao, Chun-Feng Mei, Xiao-Bin Zao and Yong-An Ye |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Pilot Project for Enhancing Clinical Research and Technology Transfer Capabilities |
DZMG-XZYY-23003 |
| Science, Technology and Innovation Specialization 2023 |
DZMKJCX-2023-014 |
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| Corresponding Author |
Yong-An Ye, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang Road, Dongcheng District, Beijing 100700, China. yeyonganvip@163.com |
| Key Words |
Chronic hepatitis B; Functional cure; Immune regulation; Immune exhaustion; Therapeutic strategies |
| Core Tip |
Functional cure of chronic hepatitis B is constrained by persistent viral reservoirs and sustained antigen-driven immune dysfunction. This dysfunction includes hepatitis B virus-specific T-cell exhaustion, B-cell dysfunction, hepatic immune tolerance, innate immune dysregulation, and metabolic and gut-liver axis remodeling. This review links these mechanisms to emerging therapies and outlines a staged strategy for durable HBsAg loss. Viral antigen reduction is followed by restoration of antiviral immunity using pegylated interferon, therapeutic vaccination, immune checkpoint modulation, or innate immune activation. Human clinical evidence has not yet established an optimal treatment sequence; biomarker-guided stratification and rational sequencing may help balance efficacy against immune-mediated liver injury. |
| Citation |
Cheng FE, Zheng SH, Qi WY, Zhao XY, Mei CF, Zao XB, Ye YA. Advances in the immunological basis and therapeutic strategies for functional cure of chronic hepatitis B. World J Gastroenterol 2026; In press
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| PDF |
126999-in-press.pdf
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Received |
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2026-08-19 02:53 |
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Peer-Review Started |
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2026-08-19 02:53 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-02 06:16 |
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Revised |
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2026-09-14 13:55 |
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Publication Fee Transferred |
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2026-10-08 14:18 |
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Second Decision by Editor |
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2026-11-12 06:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-12 10:04 |
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Articles in Press |
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2026-11-12 10:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
