Publication Name	World Journal of Methodology
Manuscript ID	127036
DOI	10.5662/wjm.127036
Country	China

Category	Neurosciences
Manuscript Type	Minireviews
Article Title	Methodological advances in understanding essential tremor: Integrating neuroimaging, genetics, and environmental exposure assessment
Manuscript Source	Invited Manuscript
All Author List	Yu-Jie Zhao, Zi-Fan Zhu, Hao-Gang Li, Yi-Xiang Huang, Mei Chen, Xiao-Hui Huang, Shu-Er Liu and Zheng Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32260175 the Guangxi Science and Technology Program GKLT2600640059
Corresponding Author	Zheng Liu, Full Professor, Head, MD, PhD, Guangxi Key Laboratory of Multimodal Biomarkers and Precision Diagnosis, Guilin Medical University, No. 109 Huancheng North Second Road, Qixing District, Guilin 541004, Guangxi Zhuang Autonomous Region, China. zliu1111@163.com
Key Words	Essential tremor; Methodology; Neuroimaging; Genetics; Harmane; Gene-environment interaction
Core Tip	This methodological review synthesizes neuroimaging, genetic, and environmental exposure approaches in essential tremor research. We evaluate each method’s strengths and limitations, identifying the lack of integrated frameworks as the primary barrier to progress. We propose harmonized protocols and multi-center prospective cohorts as essential steps toward validated biomarkers and precision medicine. This synthesis provides a roadmap for methodological standardization and cross-disciplinary integration.
Citation	Zhao YJ, Zhu ZF, Li HG, Huang YX, Chen M, Huang XH, Liu SE, Liu Z. Methodological advances in understanding essential tremor: Integrating neuroimaging, genetics, and environmental exposure assessment. World J Methodol 2026; In press DOI: https://doi.org/10.5662/wjm.127036
PDF	127036-in-press.pdf

Received	2026-08-20 07:25
Peer-Review Started	2026-08-20 07:26
First Decision by Editorial Office Director
Return for Revision	2026-09-09 08:16
Revised	2026-09-21 10:34
Publication Fee Transferred
Second Decision by Editor	2026-11-12 05:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-12 10:04
Articles in Press	2026-11-12 10:04
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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