Publication Name	World Journal of Experimental Medicine
Manuscript ID	127097
DOI	10.5493/wjem.127097
Country	Yemen

Category	Oncology
Manuscript Type	Minireviews
Article Title	Mechanisms and implications of glyceraldehyde-3-phosphate dehydrogenase upregulation in cancer: Minireview
Manuscript Source	Invited Manuscript
All Author List	Haitham Al-Madhagi
Funding Agency and Grant Number
Corresponding Author	Haitham Al-Madhagi, Lecturer, Researcher, Biochemical Technology Program, Dhamar University, Dhamar 87246, Dhamār, Yemen. bio.haitham@tu.edu.ye
Key Words	Cancer; Oncotarget; Glyceraldehyde-3-phosphate dehydrogenase; Tumor microenvironment; Tumor metabolism
Core Tip	This review reframes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a multifunctional oncogenic hub, not just a glycolytic enzyme. Beyond metabolism, GAPDH stabilizes oncogene mRNAs (cyclin D1/c-Myc), activates hypoxia-inducible factor-1alpha, and drives metastasis, chemoresistance, and stemness. Targeting both its enzymatic and moonlighting roles with multi-action inhibitors (e.g., koningic acid, alternol) offers a strategic approach to exploit cancer-specific dependencies, simultaneously impairing energy production, survival, and treatment resistance despite GAPDH’s ubiquitous expression.
Citation	Al-Madhagi H. Mechanisms and implications of glyceraldehyde-3-phosphate dehydrogenase upregulation in cancer: Minireview. World J Exp Med 2026; In press DOI: https://doi.org/10.5493/wjem.127097
PDF	127097-in-press.pdf

Received	2026-08-21 07:35
Peer-Review Started	2026-08-21 07:35
First Decision by Editorial Office Director
Return for Revision	2026-09-03 09:53
Revised	2026-09-04 14:07
Publication Fee Transferred
Second Decision by Editor	2026-09-22 03:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-22 10:02
Articles in Press	2026-09-22 10:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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