Publication Name	World Journal of Gastroenterology
Manuscript ID	127120
DOI	10.3748/wjg.127120
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Clinicopathologic and biomolecular features of interval colorectal cancers in Korean patients: A KASID multicenter prospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Joo Hye Song, Jeong Eun Shin, Dae Sung Kim, Yoo Jin Lee, Hee Chan Yang, Kyeong Ok Kim, Jae Hyun Kim, Gyeong Hoon Kang, Sung Ryul Shim and Kyu Chan Huh
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea NRF-2017R1A2B2006514
Corresponding Author	Kyu Chan Huh, Department of Internal Medicine, Konyang University Hospital, Konyang University College of Medicine, 158 Gwanjeodong-ro, Seo-gu, Daejeon 03050, South Korea. kchuh@kyuh.ac.kr
Key Words	Interval colorectal neoplasm; Etiology; Colonoscopy; CpG island methylator phenotype; Asia
Core Tip	This is the first study regarding the clinicopathological and biomolecular features of Korean patients with interval colorectal cancers (CRC). In our study, interval CRC were more common in males and located in the left colon, consistent with previous Asian, but in contrast to Western studies. The risk factors associated with survival were advanced stages and CpG island methylator phenotype (CIMP) (+). On the other hand, microsatellite instability (MSI) and BRAF (+) were protective factors for survival. Similar to western studies, CIMP was higher in interval CRCs. However, MSI, and BRAF mutations were not higher in interval CRCs, than sporadic CRCs, in contrast to Western studies.
Citation	Song JH, Shin JE, Kim DS, Lee YJ, Yang HC, Kim KO, Kim JH, Kang GH, Shim SR, Huh KC. Clinicopathologic and biomolecular features of interval colorectal cancers in Korean patients: A KASID multicenter prospective study. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.127120
PDF	127120-in-press.pdf

Received	2026-08-24 02:26
Peer-Review Started	2026-08-24 02:27
First Decision by Editorial Office Director
Return for Revision	2026-09-09 07:15
Revised	2026-09-22 14:05
Publication Fee Transferred	2026-10-10 06:46
Second Decision by Editor	2026-10-29 07:08
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-29 10:33
Articles in Press	2026-10-29 10:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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