Publication Name	World Journal of Gastroenterology
Manuscript ID	127135
DOI	10.3748/wjg.127135
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Immunosenescence and microbial ecology in gastrointestinal and hepatobiliary infection-associated cancers
Manuscript Source	Invited Manuscript
All Author List	Wen-Ge Li and Xin Yu
Funding Agency and Grant Number	Funding Agency Grant Number Fujian Provincial Health Commission 2025-S-wq14 Natural Science Foundation of Fujian Province 2026J001185
Corresponding Author	Wen-Ge Li, MD, Department of Oncology, Fuzhou Pulmonary Hospital of Fujian, No. 8 Beiyuan Road, Cangshan District, Fuzhou 350008, Fujian Province, China. 2012302180081@whu.edu.cn
Key Words	Immunosenescence; Microbiota; Helicobacter pylori; Gastric neoplasms; Hepatocellular carcinoma; Cholangiocarcinoma; Viral hepatitis; Infection-associated cancer
Core Tip	This review integrates immunosenescence and compartment-specific microbial ecology within the context of gastrointestinal and hepatobiliary infection-associated cancers. We distinguish immunosenescence from T-cell exhaustion and cellular senescence, and compare evidence across Helicobacter pylori-associated gastric cancer, hepatitis B/C virus-associated hepatocellular carcinoma, and liver-fluke-associated cholangiocarcinoma, with colorectal cancer as a mechanistic comparator. Particular attention is given to anatomical compartment, evidence directness, disease stage, and reversibility after pathogen control. Current evidence supports several mechanistic links, but a complete microbiota–immune aging–cancer causal sequence in humans remains unproven. These considerations support a pathogen-first approach to clinical translation and highlight priorities for longitudinal, compartment-matched studies.
Citation	Li WG, Yu X. Immunosenescence and microbial ecology in gastrointestinal and hepatobiliary infection-associated cancers. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.127135
PDF	127135-in-press.pdf

Received	2026-08-24 11:00
Peer-Review Started	2026-08-24 11:01
First Decision by Editorial Office Director
Return for Revision	2026-09-07 08:11
Revised	2026-09-19 02:51
Publication Fee Transferred
Second Decision by Editor	2026-10-28 07:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:43
Articles in Press	2026-10-28 10:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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