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Articles in Press
11/4/2026 10:48:57 AM | Browse: 11 | Download: 1
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Emerging histone post-translational modifications in colorectal cancer progression: Mechanisms, immune modulation, and therapeutic implications
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yang-Yang Han, Ming-Hui Yao, Zheng-Wei Hou, Nian-Lu Li and Meng-Jia Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 32300465 and No. 82260493 |
| the Fundamental Research Funds for the Universities in Xinjiang Uygur Autonomous Region |
No. XJEDU2026P047 |
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| Corresponding Author |
Meng-Jia Li, PhD, Professor, Department of Biology, School of Basic Medical Sciences, Xinjiang Medical University, No. 567 Shangde North Road, Urumqi 830017, Xinjiang Uygur Autonomous Region, China. mengjiali@xjmu.edu.cn |
| Key Words |
Colorectal cancer; Histone post-translational modifications; Histone lactylation; Tumor microenvironment; Metabolic reprogramming |
| Core Tip |
Emerging histone post-translational modifications (HPTMs) connect metabolic reprogramming with epigenetic regulation in colorectal cancer (CRC). This review critically examines six emerging HPTMs – lactylation, crotonylation, citrullination, succinylation, propionylation, and monoaminylation – with emphasis on their roles in tumor progression, immune regulation, metastasis, and treatment resistance. Importantly, we distinguish direct human CRC evidence from CRC experimental, other-cancer, and noncancer evidence. We further discuss the emerging crosstalk linking HPTMs with epigenetic and metabolic regulation, together with advances in HPTM detection and potential therapeutic opportunities. Current evidence remains heterogeneous and predominantly preclinical, underscoring the need for further mechanistic and clinical validation. |
| Citation |
Han YY, Yao MH, Hou ZW, Li NL, Li MJ. Emerging histone post-translational modifications in colorectal cancer progression: Mechanisms, immune modulation, and therapeutic implications. World J Gastroenterol 2026; In press
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| PDF |
127161-in-press.pdf
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Received |
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2026-08-24 03:44 |
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Peer-Review Started |
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2026-08-24 03:45 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-02 02:04 |
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Revised |
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2026-09-14 15:14 |
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Publication Fee Transferred |
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2026-09-29 09:48 |
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Second Decision by Editor |
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2026-11-02 02:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-04 10:48 |
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Articles in Press |
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2026-11-04 10:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
