Publication Name	World Journal of Gastroenterology
Manuscript ID	127198
DOI	10.3748/wjg.127198
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Biliary microbiota-associated α-tocopherol is linked to suppression of pancreatic ductal adenocarcinoma via G protein subunit γ10-mediated PI3K/AKT-p21 axis
Manuscript Source	Unsolicited Manuscript
All Author List	Yao Li, Zi-Gui Zou, Dong-Ming Zhu, Rui Li, Jia-Qing Shen, Qiao-Ming Zhi, Hui Yao, Xin Gao and Chen-Guang Dai
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Program of Suzhou No. SYW2025090
Corresponding Author	Chen-Guang Dai, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. daicg_soochow@163.com
Key Words	Pancreatic ductal adenocarcinoma; Biliary microbiota; α-Tocopherol; G protein subunit γ10; Phosphoinositide 3-kinase/protein kinase B signaling pathway; Cell cycle arrest; Cell proliferation
Core Tip	Pancreatic ductal adenocarcinoma is associated with distinct biliary microbial and metabolic signatures that enable discriminative diagnosis. Depletion of microbiota-associated α-tocopherol (α-Toc) is linked to tumorigenesis. Mechanistically, α-Toc activates G protein subunit γ10, dephosphorylates phosphoinositide 3-kinase and AKT, induces p21, and triggers G0/G1 cell cycle arrest, thereby suppressing pancreatic ductal adenocarcinoma oncogenesis. All these effects are fully abolished upon G protein subunit γ10 silencing. Restoration of α-Toc reactivates this tumor-suppressive pathway, supporting its role as a candidate dual diagnostic-therapeutic axis.
Citation	Li Y, Zou ZG, Zhu DM, Li R, Shen JQ, Zhi QM, Yao H, Gao X, Dai CG. Biliary microbiota-associated α-tocopherol is linked to suppression of pancreatic ductal adenocarcinoma via G protein subunit γ10-mediated PI3K/AKT-p21 axis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.127198
PDF	127198-in-press.pdf

Received	2026-08-24 07:30
Peer-Review Started	2026-08-24 07:30
First Decision by Editorial Office Director
Return for Revision	2026-09-02 08:18
Revised	2026-09-15 11:54
Publication Fee Transferred	2026-09-23 13:45
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:49
Articles in Press	2026-11-04 10:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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