Publication Name	World Journal of Psychiatry
Manuscript ID	127252
DOI	10.5498/wjp.127252
Country	China

Category	Psychology
Manuscript Type	Review
Article Title	Progress in research on the inflammatory and immunological mechanisms and interventions for the comorbidity of psoriasis and depression
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Ping Sun, Rui Yuan, Qiong Zhang and Su-Qing Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82474505
Corresponding Author	Su-Qing Yang, MD, Dermatology Department, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Dermatology Department，First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin，No.26, Heping Road, Xiangfang District, Harbin 150000, Heilongjiang Province, China. ysq_1964@163.com
Key Words	Psoriasis; Psoriatic arthritis; Depression; Comorbidity; Inflammatory and immune mechanisms; Th17/IL-17 axis; Kynurenine pathway; Biologics
Core Tip	Shared inflammatory and immune pathways are proposed to link psoriasis and depression, though the causal chain from peripheral inflammation to central symptoms remains incompletely validated in comorbid patients. IL-23/Th17-derived cytokines, hypothalamic-pituitary-adrenal axis dysregulation, kynurenine pathway shifts, central sensitization, impaired brain-derived neurotrophic factor signaling, and gut dysbiosis may converge on emotional regulation circuits. Biologics and small molecules target skin/joint inflammation; antidepressants and psychological interventions directly target depressive symptoms; lifestyle interventions reduce global burden. Evidence with formally diagnosed depression as a primary endpoint is still lacking.
Citation	Sun YP, Yuan R, Zhang Q, Yang SQ. Progress in research on the inflammatory and immunological mechanisms and interventions for the comorbidity of psoriasis and depression. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.127252
PDF	127252-in-press.pdf

Received	2026-09-08 11:09
Peer-Review Started	2026-09-08 11:09
First Decision by Editorial Office Director
Return for Revision	2026-09-23 07:05
Revised	2026-09-30 06:10
Publication Fee Transferred	2026-10-30 03:52
Second Decision by Editor	2026-11-05 01:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 09:17
Articles in Press	2026-11-05 09:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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