Publication Name	World Journal of Nephrology
Manuscript ID	127297
Country	Egypt

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Roselle-chia seed oil nutraceutical mitigates ethylene glycol-induced nephrolithiasis: Associations with renin gene expression and gut microbiota
Manuscript Source	Invited Manuscript
All Author List	Doha Abdou Mohamed, Hoda Bakr Mabrok, Enas Sabry Kotb Al-Siedy, Shaimaa El-Sayed Mohammed and Asmaa Abdelmohsen Ramadan
Funding Agency and Grant Number	Funding Agency Grant Number National Research Centre, Egypt No. 13050203
Corresponding Author	Doha Abdou Mohamed, Additional Professor, Department of Nutrition and Food Science, Food Industries and Nutrition Institute, National Research Centre, 33 El Buhouth Street, Dokki, Cairo 12622, Egypt. dohaabdomohamed@gmail.com
Key Words	Nephrolithiasis; Ethylene glycol; Roselle (Hibiscus sabdariffa); Chia seed oil; Fructooligosaccharides; Gut microbiota; Renin gene expression
Core Tip	This study evaluated a roselle-chia seed oil nutraceutical (RCSN) in an ethylene glycol-induced nephrolithiasis model. RCSN improved renal filtration, urinary parameters, electrolyte and mineral balance, and plasma renal biomarkers, while reducing oxidative stress and interleukin-6-associated inflammation. RCSN also downregulated renal renin gene expression and was associated with changes in gut microbial composition. The high dose produced greater improvements for several measured parameters, including urine volume. These findings suggest that the antioxidant and anti-inflammatory properties of RCSN, together with renin-related and microbiota-associated effects, may contribute to the observed renal and urinary improvements and support further investigation of RCSN in ethylene glycol-associated renal injury and calcium oxalate crystalluria.
Citation	Mohamed DA, Mabrok HB, Al-Siedy ESK, Mohammed SE, Ramadan AA. Roselle-chia seed oil nutraceutical mitigates ethylene glycol-induced nephrolithiasis: Associations with renin gene expression and gut microbiota. World J Nephrol 2026; In press

Received	2026-08-26 06:36
Peer-Review Started	2026-08-26 06:36
First Decision by Editorial Office Director
Return for Revision	2026-09-07 03:34
Revised	2026-09-18 12:10
Publication Fee Transferred
Second Decision by Editor	2026-11-10 03:03
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-10 10:31
Articles in Press	2026-11-10 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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