Publication Name	World Journal of Translational Medicine
Manuscript ID	127329
DOI	10.5528/wjtm.127329
Country	India

Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Molecularly guided therapy in gastrointestinal malignancies: From established targets to resistance and emerging precision strategies
Manuscript Source	Unsolicited Manuscript
All Author List	Himanshu Agrawal, Sahil Goel and Nikhil Gupta
Funding Agency and Grant Number
Corresponding Author	Himanshu Agrawal, Associate Professor, Department of Surgery, University College of Medical Sciences (University of Delhi), GTB Hospital, Dilshad Garden, Delhi 110095, India. himagr1987@gmail.com
Key Words	Gastrointestinal neoplasms; Precision medicine; Tumor biomarkers; Neoplasm drug resistance; Antineoplastic agents
Core Tip	Molecularly targeted therapy has transformed the management of selected gastrointestinal malignancies by linking specific genomic or protein alterations to individualized treatment. This narrative review summarizes established and emerging molecular targets across colorectal, gastric and gastroesophageal junction, biliary, pancreatic, and gastrointestinal stromal tumors, while contextualizing therapies according to clinical evidence, biomarker requirements, and resistance mechanisms. Emerging approaches—including circulating tumor DNA, antibody–drug conjugates, bispecific antibodies, KRAS-directed therapies, and targeted–immunotherapy combinations—may help address treatment resistance, although their clinical roles vary in maturity and require continued prospective evaluation.
Citation	Agrawal H, Goel S, Gupta N. Molecularly guided therapy in gastrointestinal malignancies: From established targets to resistance and emerging precision strategies. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.127329

Received	2026-08-27 03:11
Peer-Review Started	2026-08-27 03:11
First Decision by Editorial Office Director
Return for Revision	2026-09-16 08:52
Revised	2026-09-21 06:36
Publication Fee Transferred
Second Decision by Editor	2026-10-30 03:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-30 03:28
Articles in Press	2026-10-30 03:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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