Publication Name	World Journal of Gastroenterology
Manuscript ID	127331
DOI	10.3748/wjg.127331
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Randomized trial of vonoprazan dual therapy vs bismuth-containing quadruple therapy with two low-resistance antibiotics for Helicobacter pylori eradication
Manuscript Source	Unsolicited Manuscript
All Author List	Jian-Hong Chen, Xiao-Wen Liu, Yan-Ting Xu, Ning Wang, Jun-Feng Guo, Lu-Yang Chen, Fu-Sheng Gao and Chuan Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81900505 Beijing Municipal Administration of Hospitals’ Youth Program QML20200702
Corresponding Author	Chuan Zhang, MD, Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing 100730, China. digestivezhang@163.com
Key Words	Helicobacter pylori; Vonoprazan; Amoxicillin; Minocycline; Eradication; Safety; Randomized controlled trial
Core Tip	This single-center, open-label randomized trial compared vonoprazan-amoxicillin (VA) dual therapy with vonoprazan-based bismuth-containing quadruple therapy containing amoxicillin and minocycline (VBAM) in treatment-naïve Helicobacter pylori infection. VA was non-inferior to VBAM in eradication rates across all analysis sets. Overall adverse events were comparable, but VA had fewer dizziness events. From a healthcare payer perspective, VA had lower direct medical costs. However, the generalizability of these findings to broader populations and different resistance patterns requires further investigation.
Citation	Chen JH, Liu XW, Xu YT, Wang N, Guo JF, Chen LY, Gao FS, Zhang C. Randomized trial of vonoprazan dual therapy vs bismuth-containing quadruple therapy with two low-resistance antibiotics for Helicobacter pylori eradication. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.127331
PDF	127331-in-press.pdf

Received	2026-08-28 02:54
Peer-Review Started	2026-08-28 02:54
First Decision by Editorial Office Director
Return for Revision	2026-09-07 09:24
Revised	2026-09-20 10:44
Publication Fee Transferred	2026-10-10 10:12
Second Decision by Editor	2026-11-02 02:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:51
Articles in Press	2026-11-04 10:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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