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Articles in Press
11/9/2026 11:24:36 AM | Browse: 0 | Download: 0
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Grape seed proanthocyanidin extract attenuates high glucose-induced epithelial-mesenchymal transition of podocytes and alleviates streptozotocin diabetic renal injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Fang Zheng and Lian Jiang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Lian Jiang, Department of Pediatrics, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang City, Hebei Province, China, Shijiazhuang 050000, Hebei, China. 46100280@hebmu.edu.cn |
| Key Words |
Diabetic nephropathy; Grape seed proanthocyanidin extract; Podocytes; Epithelial-mesenchymal transition; Oxidative stress; Streptozotocin; Rat model |
| Core Tip |
This study investigated the association between grape seed proanthocyanidin extract (GSPE) and podocyte epithelial-mesenchymal transition (EMT), as well as its potential role in alleviating renal injury in diabetic nephropathy (DN). GSPE attenuated high glucose-induced EMT and abnormal migration in human podocytes, which may be associated with the transforming growth factor-β1/Smad signaling pathway. GSPE alleviated oxidative stress injury and improved hepatic and renal function in diabetic rats, thereby contributing to delaying progression of DN. |
| Citation |
Zheng ZF, Jiang L. Grape seed proanthocyanidin extract attenuates high glucose-induced epithelial-mesenchymal transition of podocytes and alleviates streptozotocin diabetic renal injury. World J Diabetes 2026; In press
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Received |
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2026-08-27 02:56 |
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Peer-Review Started |
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2026-09-09 09:28 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-20 02:14 |
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Revised |
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2026-09-29 23:37 |
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Publication Fee Transferred |
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2026-10-15 07:59 |
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Second Decision by Editor |
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2026-11-02 03:21 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-09 11:24 |
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Articles in Press |
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2026-11-09 11:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
