Publication Name	World Journal of Gastroenterology
Manuscript ID	127440
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Reply: Helicobacter pylori eradication in aspirin users gastroprotection established, cardiovascular implications to be clarified
Manuscript Source	Unsolicited Manuscript
All Author List	Amira AA Othman
Funding Agency and Grant Number
Corresponding Author	Amira AA Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Helicobacter pylori; Aspirin; Peptic ulcer bleeding; Cardiovascular disease; Eradication therapy; Gastroprotection; Observational study
Core Tip	This reply to a letter to the editor clarifies methodological choices in our study of Helicobacter pylori eradication in chronic aspirin users. We address concerns regarding the composite cardiovascular endpoint, short follow-up duration, residual confounding, eradication rate, and antithrombotic heterogeneity. Our analyses show that the observed associations remained significant after adjustment and sensitivity testing, with the gastroprotective benefit well-supported by independent randomized evidence and the cardiovascular findings consistently framed as hypothesis-generating rather than as evidence of a specific cardiovascular effect of eradication.
Citation	Othman AAA. Reply: Helicobacter pylori eradication in aspirin users gastroprotection established, cardiovascular implications to be clarified. World J Gastroenterol 2026; In press

Received	2026-08-31 02:37
Peer-Review Started	2026-08-31 02:37
First Decision by Editorial Office Director
Return for Revision	2026-09-24 07:13
Revised	2026-09-24 14:42
Publication Fee Transferred
Second Decision by Editor	2026-11-09 06:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-09 11:26
Articles in Press	2026-11-09 11:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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