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Articles in Press
11/11/2026 10:13:54 AM | Browse: 24 | Download: 5
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Associations among family history of hepatitis B virus, baseline hepatitis B surface antigen and surface antigen clearance
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Li, Hong-Yue Guo, Yi-Wen Zhang, Qin Du, Jing-Zhe Zhang, Jia-Yin Wang, Chao Yang, Fang Wang, Wei-Li Yin, Yan-Chao Fu, Feng-Hui Li, Jun-Qing Yan, Qing Ye and Hui-Ling Xiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tianjin Science and Technology Plan Project |
No. 25ZXWZSY00080 |
| Hebei Provincial Scientific Research Project of Traditional Chinese Medicine |
No. T2026008 |
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| Corresponding Author |
Hui-Ling Xiang, MD, Department of Gastroenterology and Hepatology, Central Hospital, Tianjin University/Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Institute of Hepatobiliary Disease, No. 83 Jintang Road, Hedong District, Tianjin 300170, China. huilingxiang@163.com |
| Key Words |
Chronic hepatitis B; Hepatitis B virus family history; Pegylated interferon-α; Hepatitis B surface antigen clearance; Mediation analysis |
| Core Tip |
Hepatitis B virus family history (HBFH) is significantly associated with a lower hazard of pegylated interferon-α-induced hepatitis B surface antigen (HBsAg) clearance in patients with chronic hepatitis B. Approximately 37% of this negative association is mediated by elevated baseline HBsAg levels. Model-based analysis further suggested that HBFH-positive patients may require a lower baseline HBsAg level to achieve a probability of HBsAg clearance comparable to that of HBFH-negative patients. |
| Citation |
Li J, Guo HY, Zhang YW, Du Q, Zhang JZ, Wang JY, Yang C, Wang F, Yin WL, Fu YC, Li FH, Yan JQ, Ye Q, Xiang HL. Associations among family history of hepatitis B virus, baseline hepatitis B surface antigen and surface antigen clearance. World J Gastroenterol 2026; In press
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| PDF |
127443-in-press.pdf
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Received |
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2026-08-31 06:47 |
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Peer-Review Started |
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2026-08-31 06:47 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-09-20 07:45 |
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Revised |
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2026-10-03 21:01 |
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Publication Fee Transferred |
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2026-11-02 12:44 |
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Second Decision by Editor |
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2026-11-11 06:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-11 10:13 |
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Articles in Press |
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2026-11-11 10:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
