Publication Name	World Journal of Gastroenterology
Manuscript ID	127640
DOI	10.3748/wjg.127640
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Reply to "LTE: Helicobacter pylori eradication in chronic aspirin users - a gastrointestinal strategy with cardiovascular implications?"
Manuscript Source	Unsolicited Manuscript
All Author List	Amira A. A Othman
Funding Agency and Grant Number
Corresponding Author	Amira A. A Othman, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Suez, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Helicobacter pylori; Low-dose aspirin; Peptic ulcer bleeding; Cardiovascular disease; Eradication therapy; Gastroprotection
Core Tip	This reply acknowledges a supportive commentary on our study of Helicobacter pylori eradication in chronic low-dose aspirin users. We agree with the commentator that our findings provide robust evidence for the gastroprotective benefit of eradication, consistent with the HEAT trial, and that the association between persistent infection and cardiovascular progression suggests a systemic biological interaction. We concur that H. pylori status may represent a modifiable factor within an integrated gastrointestinal-cardiovascular risk framework and that randomized trials are needed to clarify the cardiovascular implications. The cardiovascular findings are observational, potentially confounded, and not practice-changing.
Citation	Othman AAA. Letter to the Editor: Helicobacter pylori eradication in chronic aspirin users: Gastrointestinal strategy and cardiovascular implications. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.127640
PDF	127640-in-press.pdf

Received	2026-09-03 08:19
Peer-Review Started	2026-09-03 08:20
First Decision by Editorial Office Director
Return for Revision	2026-09-08 06:09
Revised	2026-09-08 13:33
Publication Fee Transferred
Second Decision by Editor	2026-11-13 03:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-13 10:28
Articles in Press	2026-11-13 10:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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