Publication Name	World Journal of Clinical Cases
Manuscript ID	127697
DOI	10.12998/wjcc.127697
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Hepatocellular pattern is compatible with fenbendazole-associated drug-induced liver injury
Manuscript Source	Unsolicited Manuscript
All Author List	Arunkumar Krishnan and Tinsay A Woreta
Funding Agency and Grant Number
Corresponding Author	Arunkumar Krishnan, MD, Department of Medicine, Atrium Health Levine Cancer, 1021 Morehead Medical Dr, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Key Words	Fenbendazole; Drug-induced liver injury; Hepatocellular injury; Immune checkpoint inhibitor; Roussel Uclaf Causality Assessment Method; Tumor onconecrosis
Core Tip	Modest alkaline phosphatase elevation does not contradict hepatocellular drug-induced liver injury, and the aspartate aminotransferase:alanine aminotransferase ratio cannot establish tumor onconecrosis. Our original clinical assessment favored fenbendazole-associated injury on the overall course, with residual uncertainty from co-exposures. The reported R ratio and Roussel Uclaf Causality Assessment Method score remain unresolved verification needs rather than established errors; this limitation does not validate an alternative mechanism. Severe liver injury should prompt clinical evaluation and should not be interpreted as evidence of anticancer efficacy.
Citation	Krishnan A, Woreta TA. Letter to the Editor: Hepatocellular pattern is compatible with fenbendazole-associated drug-induced liver injury. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.127697
PDF	127697-in-press.pdf

Received	2026-09-04 03:18
Peer-Review Started	2026-09-04 03:20
First Decision by Editorial Office Director
Return for Revision	2026-09-28 01:17
Revised	2026-10-01 18:54
Publication Fee Transferred
Second Decision by Editor	2026-10-12 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-12 10:10
Articles in Press	2026-10-12 10:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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