Publication Name	World Journal of Clinical Cases
Manuscript ID	81413
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Yiwei Xiaoyu Granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach
Manuscript Source	Unsolicited Manuscript
All Author List	Wan-Qun Chen, Qing-Feng Fan, Yuan-Jun He, Fei Li, Xin Wu, Yan-Ping Li and Xiao-Jun Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81904175 Chongqing Health Planning Commission Project ZY201802063 Chongqing Health Planning Commission Project 2019ZY013111 Chongqing Technology Innovation and Application development special key project CSTB2022TIAD-KPX0187 Chongqing Health Planning Commission Project 2022QNXM061
Corresponding Author	Xiao-Jun Yang, PhD, Doctor, Department of Gastroenterology, Chongqing Hospital of Traditional Chinese Medicine, No. 6 Panxi Seven Branch Road, Jiangbei District, Chongqing 400000, China. yxj20220606@163.com
Key Words	Chronic atrophic gastritis; Yiwei Xiaoyu granules; Randomized clinical trial; Weifuchun tablet; Traditional Chinese medicine; Helicobacter pylori
Core Tip	Despite the successful eradication of Helicobacter pylori (H. pylori), which has been shown to reduce the risk of gastric cancer (GC), patients with chronic atrophic gastritis (CAG) still remain susceptible to disease progression leading to GC. Our findings suggest that treatment with Yiwei Xiaoyu granules for CAG patients without H. pylori improved the stage of Operative Link on Gastric Intestinal Metaplasia Assessment, provided better clinical symptoms relief and better improvement in serum gastric function levels compared to Weifuchun tablet. However, the total sample size of this study is limited and prolong follow-up hasn’t been carried out.
Citation	Chen WQ, Fan QF, He YJ, Li F, Wu X, Li YP, Yang XJ. Yiwei Xiaoyu Granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach. World J Clin Cases 2024; 12(13): 2201-2209

Received	2024-01-11 13:08
Peer-Review Started	2024-01-11 13:08
To Make the First Decision
Return for Revision	2024-02-26 14:35
Revised	2024-03-03 07:06
Second Decision	2024-04-01 01:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-01 08:16
Articles in Press	2024-04-01 08:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-15 01:54

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com