Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	87150
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Jing Zhang, Ke-Lin Yue, Jing-Zhai Wang and Yu Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82260601 Joint Foundation of Kunming Medical University and Yunnan Provincial Science and Technology Department 202201AY070001-256 Grant for Clinical Medical Center of Yunnan Provincial Health Commission 2021LCZXXF-XH03 Young Academic Talents Cultivation Foundation of Yunnan Province 202205AC160070
Corresponding Author	Yu Zhang, MD, PhD, Associate Professor, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan Province, China. yuzhang320@sina.com
Key Words	Colorectal cancer; DNA methylation; Prognosis; Diagnosis; Bioinformatics; Heat shock factor protein 4
Core Tip	Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with clinical manifestations of diarrhea, constipation, and abdominal pain. We previously demonstrated that heat shock factor protein 4 (HSF4) accelerates the malignant biological behavior of CRC cells in vivo and in vitro. This study reveals that HSF4 is highly methylated and associated with HSF4 overexpression in CRC. Although the diagnostic and prognostic value of HSF4 methylation is poor, it may be involved in the process of CRC by mediating the expression of HSF4 or related genes. Combined with the finding of our previous study, the present study suggests that the high expression of HSF4 mRNA and protein and its oncogenic effects are likely to be associated with HSF4 methylation.
Citation	Zhang WJ, Yue KL, Wang JZ, Zhang Y. Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study. World J Gastrointest Oncol 2023; 15(12): 2150-2168

Received	2023-07-28 01:38
Peer-Review Started	2023-07-28 01:40
To Make the First Decision
Return for Revision	2023-09-26 20:35
Revised	2023-10-16 12:01
Second Decision	2023-11-13 00:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-11-17 09:02
Articles in Press	2023-11-17 09:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-12-06 09:37

ISSN	1948-5204 (online)
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