BPG is committed to discovery and dissemination of knowledge
Articles in Press
11/17/2023 9:02:31 AM | Browse: 40 | Download: 2
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 87150
Country/Territory China
Category Biochemistry & Molecular Biology
Manuscript Type Basic Study
Article Title Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study
Manuscript Source Unsolicited Manuscript
All Author List Wen-Jing Zhang, Ke-Lin Yue, Jing-Zhai Wang and Yu Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82260601
Joint Foundation of Kunming Medical University and Yunnan Provincial Science and Technology Department 202201AY070001-256
Grant for Clinical Medical Center of Yunnan Provincial Health Commission 2021LCZXXF-XH03
Young Academic Talents Cultivation Foundation of Yunnan Province 202205AC160070
Corresponding Author Yu Zhang, MD, PhD, Associate Professor, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan Province, China. yuzhang320@sina.com
Key Words Colorectal cancer; DNA methylation; Prognosis; Diagnosis; Bioinformatics; Heat shock factor protein 4
Core Tip Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with clinical manifestations of diarrhea, constipation, and abdominal pain. We previously demonstrated that heat shock factor protein 4 (HSF4) accelerates the malignant biological behavior of CRC cells in vivo and in vitro. This study reveals that HSF4 is highly methylated and associated with HSF4 overexpression in CRC. Although the diagnostic and prognostic value of HSF4 methylation is poor, it may be involved in the process of CRC by mediating the expression of HSF4 or related genes. Combined with the finding of our previous study, the present study suggests that the high expression of HSF4 mRNA and protein and its oncogenic effects are likely to be associated with HSF4 methylation.
Citation Zhang WJ, Yue KL, Wang JZ, Zhang Y. Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study. World J Gastrointest Oncol 2023; In press
2023-07-28 01:38
Peer-Review Started
2023-07-28 01:40
To Make the First Decision
Return for Revision
2023-09-26 20:35
2023-10-16 12:01
Second Decision
2023-11-13 00:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-11-17 09:02
Articles in Press
2023-11-17 09:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jing-Jie Wang
Reviewer Code 05480683, 03031516, 03031311, and 03522829
Editorial Director
Journal Chief Editor
Company Chief Editor Jin-Lei Wang
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma