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11/17/2023 8:56:22 AM | Browse: 36 | Download: 20

Publication Name	World Journal of Stem Cells
Manuscript ID	87928
Country/Territory	China

Category

Transplantation

Manuscript Type

Basic Study

Article Title

Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway

Manuscript Source

Unsolicited Manuscript

All Author List

Bin Hu, Xiang-Xi Zhang, Tao Zhang and Wan-Cheng Yu

Funding Agency and Grant Number

Funding Agency	Grant Number
Natural Science Foundation of Shandong Province of China	ZR2021QH179, ZR2020MH014

Corresponding Author

Wan-Cheng Yu, Doctor, MD, Postdoc, Surgeon, Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Jinan 250062, Shandong Province, China. yuwancheng123@126.com

Key Words

Human umbilical cord mesenchymal stem cells; Cystathionine γ-lyase/hydrogen sulfide pathway; Ferroptosis; Pulmonary arterial hypertension; S-sulfhydration

Core Tip

Regulation of the cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway in human umbilical cord mesenchymal stem cells (HUCMSCs) contributes to the inhibition of ferroptosis and improves the suppressive effect of HUCMSCs on vascular remodelling in hypoxia-induced pulmonary arterial hypertension (PAH) mice. Moreover, the protective effect of the CSE/H2S pathway against ferroptosis in HUCMSCs was mediated via S-sulfhydrated Kelch-like ECH-associating protein 1/nuclear factor erythroid 2-related factor 2 signalling. The present study may provide a novel therapeutic avenue for improving the protective capacity of transplanted MSCs in PAH.

Citation

Hu B, Zhang XX, Zhang T, Yu WC. Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway. World J Stem Cells 2023; 15(11): 1017-1034

Received

2023-09-02 14:33

Peer-Review Started

2023-09-02 14:34

To Make the First Decision

Return for Revision

2023-10-19 15:08

Revised

2023-10-25 15:38

Second Decision

2023-11-13 00:54

Accepted by Journal Editor-in-Chief

2023-11-15 08:37

Accepted by Company Editor-in-Chief

2023-11-17 08:56

Articles in Press

2023-11-17 08:56

Publication Fee Transferred

Edit the Manuscript by Language Editor

2023-11-10 05:47

Typeset the Manuscript

2023-11-21 09:05

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Assistant Editor	Assistant Editor
Science Editor	Jing-Jie Wang
Reviewer Code	03949576, 03712811, 00415501, and 03949576
Editorial Director
Journal Chief Editor	Shengwen Calvin Li
Company Chief Editor	Jin-Lei Wang
Language Editor	Tian-Qi Wang
Production Editor	Xiang-Di Zhang
Responsible Production Editor	Xiang-Di Zhang
Responsible Science Editor
Proofing Editorial Director	Jin-Lei Wang
Proofing Editor-in-Chief	Lian-Sheng Ma