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11/17/2023 8:56:22 AM | Browse: 53 | Download: 22
Publication Name World Journal of Stem Cells
Manuscript ID 87928
Country China
Category Transplantation
Manuscript Type Basic Study
Article Title Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway
Manuscript Source Unsolicited Manuscript
All Author List Bin Hu, Xiang-Xi Zhang, Tao Zhang and Wan-Cheng Yu
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Shandong Province of China ZR2021QH179, ZR2020MH014
Corresponding Author Wan-Cheng Yu, Doctor, MD, Postdoc, Surgeon, Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Jinan 250062, Shandong Province, China. yuwancheng123@126.com
Key Words Human umbilical cord mesenchymal stem cells; Cystathionine γ-lyase/hydrogen sulfide pathway; Ferroptosis; Pulmonary arterial hypertension; S-sulfhydration
Core Tip Regulation of the cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway in human umbilical cord mesenchymal stem cells (HUCMSCs) contributes to the inhibition of ferroptosis and improves the suppressive effect of HUCMSCs on vascular remodelling in hypoxia-induced pulmonary arterial hypertension (PAH) mice. Moreover, the protective effect of the CSE/H2S pathway against ferroptosis in HUCMSCs was mediated via S-sulfhydrated Kelch-like ECH-associating protein 1/nuclear factor erythroid 2-related factor 2 signalling. The present study may provide a novel therapeutic avenue for improving the protective capacity of transplanted MSCs in PAH.
Citation Hu B, Zhang XX, Zhang T, Yu WC. Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway. World J Stem Cells 2023; 15(11): 1017-1034
Received
2023-09-02 14:33
Peer-Review Started
2023-09-02 14:34
To Make the First Decision
Return for Revision
2023-10-19 15:08
Revised
2023-10-25 15:38
Second Decision
2023-11-13 00:54
Accepted by Journal Editor-in-Chief
2023-11-15 08:37
Accepted by Company Editor-in-Chief
2023-11-17 08:56
Articles in Press
2023-11-17 08:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-11-10 05:47
Typeset the Manuscript
2023-11-21 09:05
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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