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Articles in Press
11/17/2023 8:56:22 AM | Browse: 61 | Download: 22
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bin Hu, Xiang-Xi Zhang, Tao Zhang and Wan-Cheng Yu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province of China |
ZR2021QH179, ZR2020MH014 |
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| Corresponding Author |
Wan-Cheng Yu, Doctor, MD, Postdoc, Surgeon, Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Jinan 250062, Shandong Province, China. yuwancheng123@126.com |
| Key Words |
Human umbilical cord mesenchymal stem cells; Cystathionine γ-lyase/hydrogen sulfide pathway; Ferroptosis; Pulmonary arterial hypertension; S-sulfhydration |
| Core Tip |
Regulation of the cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway in human umbilical cord mesenchymal stem cells (HUCMSCs) contributes to the inhibition of ferroptosis and improves the suppressive effect of HUCMSCs on vascular remodelling in hypoxia-induced pulmonary arterial hypertension (PAH) mice. Moreover, the protective effect of the CSE/H2S pathway against ferroptosis in HUCMSCs was mediated via S-sulfhydrated Kelch-like ECH-associating protein 1/nuclear factor erythroid 2-related factor 2 signalling. The present study may provide a novel therapeutic avenue for improving the protective capacity of transplanted MSCs in PAH. |
| Citation |
Hu B, Zhang XX, Zhang T, Yu WC. Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway. World J Stem Cells 2023; 15(11): 1017-1034 |
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Received |
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2023-09-02 14:33 |
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Peer-Review Started |
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2023-09-02 14:34 |
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To Make the First Decision |
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Return for Revision |
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2023-10-19 15:08 |
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Revised |
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2023-10-25 15:38 |
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Second Decision |
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2023-11-13 00:54 |
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Accepted by Journal Editor-in-Chief |
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2023-11-15 08:37 |
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Accepted by Company Editor-in-Chief |
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2023-11-17 08:56 |
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Articles in Press |
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2023-11-17 08:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-11-10 05:47 |
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Typeset the Manuscript |
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2023-11-21 09:05 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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