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Articles in Press
11/17/2023 8:54:35 AM | Browse: 65 | Download: 3
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22Hv blunts liver regeneration
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Heng Zhou, Ju-Ling Xu, San-Xiong Huang, Ying He, Xiao-Wei He, Sheng Lu and Bin Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Zhejiang Province |
LQ20H310002 |
| Scientific Technology Projects of Health and Medicine of Zhejiang Province |
2020KY308 |
| Huzhou Science and Technology Fund |
2020GY39 |
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| Corresponding Author |
Bin Yao, BPharm, Chief Pharmacist, Department of Pharmacy, The First People’s Hospital of Huzhou, First Affiliated Hospital of Huzhou University, No. 158 Square Back Road, Wuxing District, Huzhou 313000, Zhejiang Province, China. 50228@zjhu.edu.cn |
| Key Words |
Interleukin-22; Partial hepatectomy; Hepatic vagotomy; Liver regeneration; Signal transducer and activator of transcription 3; Interleukin-22 binding protein |
| Core Tip |
In this study, we investigated the role and mechanism of the vagus nerve in liver regeneration using a partial hepatectomy (PHx) plus hepatic vagotomy (Hv) mouse model. We found that Hv attenuates liver regeneration after hepatectomy, the mechanism may be related to the fact that Hv downregulates the production of interleukin-22, then blocks activation of the signal transducer and activator of transcription 3 pathway after PHx. These results provide a theoretical basis for the development of drugs that promote liver regeneration with the vagus nerve as a new target. |
| Citation |
Zhou H, Xu JL, Huang SX, He Y, He XW, Lu S, Yao B. Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22. World J Gastrointest Surg 2023; 15(12): 2866-2878 |
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Received |
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2023-09-08 04:06 |
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Peer-Review Started |
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2023-09-08 04:08 |
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To Make the First Decision |
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Return for Revision |
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2023-10-24 06:49 |
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Revised |
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2023-11-01 04:25 |
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Second Decision |
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2023-11-13 00:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-11-17 08:54 |
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Articles in Press |
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2023-11-17 08:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-21 05:44 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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