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11/17/2023 8:54:35 AM | Browse: 61 | Download: 3
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 88060
Country China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22Hv blunts liver regeneration
Manuscript Source Unsolicited Manuscript
All Author List Heng Zhou, Ju-Ling Xu, San-Xiong Huang, Ying He, Xiao-Wei He, Sheng Lu and Bin Yao
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Zhejiang Province LQ20H310002
Scientific Technology Projects of Health and Medicine of Zhejiang Province 2020KY308
Huzhou Science and Technology Fund 2020GY39
Corresponding Author Bin Yao, BPharm, Chief Pharmacist, Department of Pharmacy, The First People’s Hospital of Huzhou, First Affiliated Hospital of Huzhou University, No. 158 Square Back Road, Wuxing District, Huzhou 313000, Zhejiang Province, China. 50228@zjhu.edu.cn
Key Words Interleukin-22; Partial hepatectomy; Hepatic vagotomy; Liver regeneration; Signal transducer and activator of transcription 3; Interleukin-22 binding protein
Core Tip In this study, we investigated the role and mechanism of the vagus nerve in liver regeneration using a partial hepatectomy (PHx) plus hepatic vagotomy (Hv) mouse model. We found that Hv attenuates liver regeneration after hepatectomy, the mechanism may be related to the fact that Hv downregulates the production of interleukin-22, then blocks activation of the signal transducer and activator of transcription 3 pathway after PHx. These results provide a theoretical basis for the development of drugs that promote liver regeneration with the vagus nerve as a new target.
Citation Zhou H, Xu JL, Huang SX, He Y, He XW, Lu S, Yao B. Hepatic vagotomy blunts liver regeneration after hepatectomy by downregulating the expression of interleukin-22. World J Gastrointest Surg 2023; 15(12): 2866-2878
Received
2023-09-08 04:06
Peer-Review Started
2023-09-08 04:08
To Make the First Decision
Return for Revision
2023-10-24 06:49
Revised
2023-11-01 04:25
Second Decision
2023-11-13 00:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-11-17 08:54
Articles in Press
2023-11-17 08:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-12-21 05:44
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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