Publication Name	World Journal of Stem Cells
Manuscript ID	88551
Country	Jordan

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment
Manuscript Source	Invited Manuscript
All Author List	Ejlal Abu-El-Rub, Fatimah Almahasneh, Ramada R Khasawneh, Ayman Alzu'bi, Doaa Ghorab, Rawan Almazari, Huthaifa Magableh, Ahmad Sanajleh, Haitham Shlool, Mohammad Mazari, Noor S Bader and Joud Al-Momani
Funding Agency and Grant Number
Corresponding Author	Ejlal Abu-El-Rub, PhD, Assistant Professor, Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid-Shafiq Irshidat Street, Irbid 21163, Jordan. ejlal.abuelrub@yu.edu.jo
Key Words	Mesenchymal stem cells; High glucose; Mitochondrial dynamics; Apoptosis; Poor survival; Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway
Core Tip	Mesenchymal stem cells (MSCs) have significant regenerative properties that make them a potential treatment for many chronic diseases. Among these, diabetes mellitus (DM) was found to benefit from MSCs transplantation in which they restored the damaged tissues and prevented hyperglycemia-related complications. However, these therapeutic are short-lived hindering the clinical use of MSCs in the treatment of DM. This study aims to elucidate the mechanisms of hyperglycemia-induced effects on MSCs which will help in improving the therapeutic functions of these cells in this stress environment.
Citation	Abu-El-Rub E, Almahasneh F, Khasawneh RR, Alzu'bi A, Ghorab D, Almazari R, Magableh H, Sanajleh A, Shlool H, Mazari M, Bader NS, Al-Momani J. Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment. World J Stem Cells 2023; 15(12): 1093-1103

Received	2023-09-28 07:30
Peer-Review Started	2023-09-28 07:32
To Make the First Decision
Return for Revision	2023-10-23 08:44
Revised	2023-11-11 20:48
Second Decision	2023-11-23 02:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-11-24 08:23
Articles in Press	2023-11-24 08:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-12-13 06:20

ISSN	1948-0210 (online)
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