Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	88566
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Effectiveness of an amino acid beverage formulation in diarrhea-predominant irritable bowel syndrome: A pragmatic real-world study
Manuscript Source	Unsolicited Manuscript
All Author List	Samantha E Niles, Phil Blazy, Samuel N Cheuvront, Robert W Kenefick, Sadasivan Vidyasagar, Adam B Smith, Neil Fawkes and William Denman
Funding Agency and Grant Number
Corresponding Author	Samantha E Niles, BSc, MS, Researcher, Department of Research and Development, Entrinsic Bioscience, 500 River Ridge Dr. 100, Norwood, MA 02062, United States. sniles@entrinsic.com
Key Words	Diarrhea-predominant irritable bowel syndrome; Amino acid beverage formulation; Pragmatic real-world study; Medical food; Bristol Stool Form Scale; Irritable Bowel Syndrome – Severity Scoring System
Core Tip	Amino-acid based medical foods have been shown to alleviate symptoms of drug induced gastrointestinal side effects, especially diarrhea severity. Diarrhea predominant irritable bowel syndrome (IBS-D) is a chronic gastrointestinal disorder that affects up to 9% of people worldwide. In this pragmatic, real-world study, an amino acid beverage was demonstrated to be tolerable and efficacious when used as an adjunct to standard of care for adults with IBS-D. Participants demonstrated improvements in both overall irritable bowel syndrome symptom severity and IBS-D symptoms within just two weeks. These results suggest that this amino acid-based beverage can be safely integrated into IBS-D standard of care for symptom improvement.
Citation	Niles SE, Blazy P, Cheuvront SN, Kenefick RW, Vidyasagar S, Smith AB, Fawkes N, Denman W. Effectiveness of an amino acid beverage formulation in diarrhea-predominant irritable bowel syndrome: A pragmatic real-world study. World J Gastrointest Pharmacol Ther 2023; 14(5): 39-49

Received	2023-09-29 14:03
Peer-Review Started	2023-09-29 14:03
To Make the First Decision
Return for Revision	2023-10-10 19:17
Revised	2023-10-16 15:14
Second Decision	2023-11-10 04:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-11-17 08:44
Articles in Press	2023-11-17 08:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-11-29 02:38

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com