Publication Name	World Journal of Gastroenterology
Manuscript ID	88575
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Zhuo-Zhen Lyu, Meng Li, Ming-Yu Yang, Mei-Hong Han and Zhen Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81972606， 82271774
Corresponding Author	Zhen Yang, MD, PhD, Doctor, Professor, Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. yangzhen@sdfmu.edu.cn
Key Words	Exosome; Cell communication; Noncoding RNA; Metal-regulatory transcription factor-1; Mesenchymal stem cells
Core Tip	We identified the functional implications and mechanisms of exosomal hsa_circ_0000563 (circ563) in hepatocellular carcinoma (HCC). Mesenchymal stem cells suppressed HCC proliferation and invasion via their exosomes. The circ563 interacts with miR-148a-3p, a molecule involved in HCC progression, and both are identified at different levels in exosomes. The tumor-promoting effects of circ563 were partially suppressed by miR-148a-3p overexpression or depletion of metal-regulatory transcription factor-1 (MTF-1). Xenograft experiments performed in nude mice confirmed that circ563-enriched exosomes facilitated tumor growth via MTF-1 upregulation. Our findings provide new insights into circ563/miR-148a-3p/MTF-1 signaling as a potential therapeutic target for HCC.
Citation	Lyu ZZ, Li M, Yang MY, Han MH, Yang Z. Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway. World J Gastroenterol 2023; 29(46): 6060-6075

Received	2023-09-29 12:37
Peer-Review Started	2023-09-29 12:39
To Make the First Decision
Return for Revision	2023-10-16 17:37
Revised	2023-10-24 18:34
Second Decision	2023-11-14 03:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-11-17 08:46
Articles in Press	2023-11-17 08:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-12-04 07:29

ISSN	1007-9327 (print) and 2219-2840 (online)
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