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11/17/2023 8:46:43 AM | Browse: 35 | Download: 3
Publication Name World Journal of Gastroenterology
Manuscript ID 88575
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway
Manuscript Source Unsolicited Manuscript
All Author List Zhuo-Zhen Lyu, Meng Li, Ming-Yu Yang, Mei-Hong Han and Zhen Yang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81972606, 82271774
Corresponding Author Zhen Yang, MD, PhD, Doctor, Professor, Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. yangzhen@sdfmu.edu.cn
Key Words Exosome; Cell communication; Noncoding RNA; Metal-regulatory transcription factor-1; Mesenchymal stem cells
Core Tip We identified the functional implications and mechanisms of exosomal hsa_circ_0000563 (circ563) in hepatocellular carcinoma (HCC). Mesenchymal stem cells suppressed HCC proliferation and invasion via their exosomes. The circ563 interacts with miR-148a-3p, a molecule involved in HCC progression, and both are identified at different levels in exosomes. The tumor-promoting effects of circ563 were partially suppressed by miR-148a-3p overexpression or depletion of metal-regulatory transcription factor-1 (MTF-1). Xenograft experiments performed in nude mice confirmed that circ563-enriched exosomes facilitated tumor growth via MTF-1 upregulation. Our findings provide new insights into circ563/miR-148a-3p/MTF-1 signaling as a potential therapeutic target for HCC.
Citation Lyu ZZ, Li M, Yang MY, Han MH, Yang Z. Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway. World J Gastroenterol 2023; In press
2023-09-29 12:37
Peer-Review Started
2023-09-29 12:39
To Make the First Decision
Return for Revision
2023-10-16 17:37
2023-10-24 18:34
Second Decision
2023-11-14 03:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-11-17 08:46
Articles in Press
2023-11-17 08:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jing-Jie Wang
Reviewer Code 03372482, and 05536533
Editorial Director
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Company Chief Editor Jin-Lei Wang
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