Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	88620
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Biological factors driving colorectal cancer metastasis
Manuscript Source	Unsolicited Manuscript
All Author List	Shuai-Xing An, Zhao-Jin Yu, Chen Fu, Min-Jie Wei and Long-Hai Shen
Funding Agency and Grant Number
Corresponding Author	Long-Hai Shen, MD, Chief Doctor, Center of Oncology, Genertec Liaoyou Gem Flower Hospital, No. 26 Yingbin Road, Zhenxing Street, Xinglongtai District, PanJin 124010, Liaoning Province, China. 154571964@qq.com
Key Words	Colorectal cancer; Metastasis cascade; Cancer immunity; Genomic variation; Epigenetic instability; Lifestyle factor
Core Tip	Metastatic colorectal cancer (CRC) is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue, allowing cancer cells to spread from primary to distant organs; however, increasing evidence suggests that this process can begin early during tumor development. CRC patients exhibit high heterogeneity and diverse cancer phenotypes that are classified based on molecular and morphological alterations. Different genomic and non-genomic events can induce sub-clone diversity, which leads to cancer and metastasis.
Citation	An SX, Yu ZJ, Fu C, Wei MJ, Shen LH. Biological factors driving colorectal cancer metastasis. World J Gastrointest Oncol 2024; 16(2): 259-272

Received	2023-10-01 23:49
Peer-Review Started	2023-10-01 23:51
To Make the First Decision
Return for Revision	2023-12-11 02:11
Revised	2023-12-23 06:40
Second Decision	2024-01-08 03:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-08 07:18
Articles in Press	2024-01-08 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-26 01:20

ISSN	1948-5204 (online)
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