Publication Name	World Journal of Radiology
Manuscript ID	88642
Country	Japan

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Basic Study
Article Title	Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters
Manuscript Source	Unsolicited Manuscript
All Author List	Winn Aung, Atsushi B Tsuji, Kazuaki Rikiyama, Fumihiko Nishikido, Satoshi Obara and Tatsuya Higashi
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 21K07740
Corresponding Author	Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Key Words	Tetrakis (4-carboxyphenyl) porphyrin; Photosensitizer emission; Radionuclide; Cherenkov radiation; Optical imaging; Long-pass filters
Core Tip	Radionuclides produce Cherenkov radiation (CR), which can potentially activate photosensitizers (PSs) in phototherapy. However, a cost-effective method to determine whether radionuclide-derived CR excites PSs and the measurement of fluorescence emitted by excited PS remain elusive. We propose a cost-effective method using a charge-coupled device optical imaging system combined with long-pass filters and subtraction image processing to distinguish CR and PS fluorescence emission. As a proof-of-concept, 64CuCl2 and the PS tetrakis (4-carboxyphenyl) porphyrin were used in the experiments. This method can contribute to accelerating the development of Cherenkov energy transfer imaging and the discovery of new PSs.
Citation	Aung W, Tsuji AB, Rikiyama K, Nishikido F, Obara S, Higashi T. Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters. World J Radiol 2023; 15(11): 315-323

Received	2023-10-03 14:33
Peer-Review Started	2023-10-03 14:34
To Make the First Decision
Return for Revision	2023-10-17 08:03
Revised	2023-10-26 18:21
Second Decision	2023-11-14 05:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-11-17 08:43
Articles in Press	2023-11-17 08:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-11-14 01:09
Typeset the Manuscript	2023-11-21 05:34

ISSN	1949-8470 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com