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11/17/2023 8:43:13 AM | Browse: 24 | Download: 6

Publication Name	World Journal of Radiology
Manuscript ID	88642
Country/Territory	Japan

Category

Radiology, Nuclear Medicine & Medical Imaging

Manuscript Type

Basic Study

Article Title

Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters

Manuscript Source

Unsolicited Manuscript

All Author List

Winn Aung, Atsushi B Tsuji, Kazuaki Rikiyama, Fumihiko Nishikido, Satoshi Obara and Tatsuya Higashi

Funding Agency and Grant Number

Funding Agency	Grant Number
Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science	21K07740

Corresponding Author

Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp

Key Words

Tetrakis (4-carboxyphenyl) porphyrin; Photosensitizer emission; Radionuclide; Cherenkov radiation; Optical imaging; Long-pass filters

Core Tip

Radionuclides produce Cherenkov radiation (CR), which can potentially activate photosensitizers (PSs) in phototherapy. However, a cost-effective method to determine whether radionuclide-derived CR excites PSs and the measurement of fluorescence emitted by excited PS remain elusive. We propose a cost-effective method using a charge-coupled device optical imaging system combined with long-pass filters and subtraction image processing to distinguish CR and PS fluorescence emission. As a proof-of-concept, 64CuCl2 and the PS tetrakis (4-carboxyphenyl) porphyrin were used in the experiments. This method can contribute to accelerating the development of Cherenkov energy transfer imaging and the discovery of new PSs.

Citation

Aung W, Tsuji AB, Rikiyama K, Nishikido F, Obara S, Higashi T. Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters. World J Radiol 2023; 15(11): 315-323

Received

2023-10-03 14:33

Peer-Review Started

2023-10-03 14:34

To Make the First Decision

Return for Revision

2023-10-17 08:03

Revised

2023-10-26 18:21

Second Decision

2023-11-14 05:13

Accepted by Journal Editor-in-Chief

Accepted by Company Editor-in-Chief

2023-11-17 08:43

Articles in Press

2023-11-17 08:43

Publication Fee Transferred

Edit the Manuscript by Language Editor

2023-11-14 01:09

Typeset the Manuscript

2023-11-21 05:34

ISSN	1949-8470 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Assistant Editor	Assistant Editor
Science Editor	Cong Lin
Reviewer Code	02519358
Editorial Director
Journal Chief Editor
Company Chief Editor	Jin-Lei Wang
Language Editor	Donna Fox
Production Editor	Si Zhao
Responsible Production Editor	Si Zhao
Responsible Science Editor
Proofing Editorial Director	Jin-Lei Wang
Proofing Editor-in-Chief	Lian-Sheng Ma