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11/17/2023 8:43:13 AM | Browse: 24 | Download: 6
Publication Name World Journal of Radiology
Manuscript ID 88642
Country/Territory Japan
Category Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type Basic Study
Article Title Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters
Manuscript Source Unsolicited Manuscript
All Author List Winn Aung, Atsushi B Tsuji, Kazuaki Rikiyama, Fumihiko Nishikido, Satoshi Obara and Tatsuya Higashi
Funding Agency and Grant Number
Funding Agency Grant Number
Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science 21K07740
Corresponding Author Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Key Words Tetrakis (4-carboxyphenyl) porphyrin; Photosensitizer emission; Radionuclide; Cherenkov radiation; Optical imaging; Long-pass filters
Core Tip Radionuclides produce Cherenkov radiation (CR), which can potentially activate photosensitizers (PSs) in phototherapy. However, a cost-effective method to determine whether radionuclide-derived CR excites PSs and the measurement of fluorescence emitted by excited PS remain elusive. We propose a cost-effective method using a charge-coupled device optical imaging system combined with long-pass filters and subtraction image processing to distinguish CR and PS fluorescence emission. As a proof-of-concept, 64CuCl2 and the PS tetrakis (4-carboxyphenyl) porphyrin were used in the experiments. This method can contribute to accelerating the development of Cherenkov energy transfer imaging and the discovery of new PSs.
Citation Aung W, Tsuji AB, Rikiyama K, Nishikido F, Obara S, Higashi T. Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters. World J Radiol 2023; 15(11): 315-323
2023-10-03 14:33
Peer-Review Started
2023-10-03 14:34
To Make the First Decision
Return for Revision
2023-10-17 08:03
2023-10-26 18:21
Second Decision
2023-11-14 05:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-11-17 08:43
Articles in Press
2023-11-17 08:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-11-14 01:09
Typeset the Manuscript
2023-11-21 05:34
ISSN 1949-8470 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Cong Lin
Reviewer Code 02519358
Editorial Director
Journal Chief Editor
Company Chief Editor Jin-Lei Wang
Language Editor Donna Fox
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