Publication Name	World Journal of Gastroenterology
Manuscript ID	88964
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Leukocyte immunoglobulin-like receptor B2: A promising biomarker for colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Zhuo Zhao, Hong-Gang Wang and Xiao-Zhong Yang
Funding Agency and Grant Number
Corresponding Author	Xiao-Zhong Yang, MD, PhD, Chief Doctor, Doctor, Doctor, Professor, Department of Gastroenterology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe Road, Huai'an 223300, Jiangsu Province, China. hayyyxzh@njmu.edu.cn
Key Words	Colorectal cancer; Leukocyte immunoglobulin-like receptor B2; Angiopoietin-like protein 2; Therapeutic target; Noninvasive screening biomarker
Core Tip	In this study, it has been extensively demonstrated that there is an overexpression of leukocyte immunoglobulin-like receptor B2 (LILRB2) and its ligand angiopoietin-like protein 2 in colorectal cancer tissues. Furthermore, these proteins have been found to be closely associated with tumor progression and poor prognosis. The author conducted an analysis of LILRB2 serum concentration using 313 serum samples and compared its advantages and disadvantages with traditional tumor markers such as carcinoembryonic antigen and carbohydrate antigen 199. However, we believe that certain aspects of data collection and analysis in the article warrant further consideration. Therefore, we would like to discuss our perspective on this intriguing research.
Citation	Zhao WZ, Wang HG, Yang XZ. Leukocyte immunoglobulin-like receptor B2: A promising biomarker for colorectal cancer. World J Gastroenterol 2024; 30(4): 421-423

Received	2023-10-17 03:42
Peer-Review Started	2023-10-17 03:44
To Make the First Decision
Return for Revision	2023-12-06 04:59
Revised	2023-12-15 16:40
Second Decision	2024-01-10 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-10 05:05
Articles in Press	2024-01-10 05:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-20 15:23

ISSN	1007-9327 (print) and 2219-2840 (online)
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