Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	89126
Country	China

Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Development of a novel staging classification for Siewert II adenocarcinoma of the esophagogastric junction after neoadjuvant chemotherapy
Manuscript Source	Unsolicited Manuscript
All Author List	Jian Zhang, Hao Liu, Hang Yu and Wei-xiang Xu
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Provincial Science and Technology Program 2023C03172
Corresponding Author	Jian Zhang, MD, Chief, Chief Doctor, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 1367 West Wenyi Road, Yuhang District, Hangzhou 310003, Zhejiang Province, China. ljzju001@126.com
Key Words	Stage classification; Prognosis; Esophagogastric junction cancer; Neoadjuvant chemotherapy; Siewert type
Core Tip	So far, the ideal staging classification for Siewert II AEG treated with neoadjuvant chemotherapy is lacking. Thus, we established nomogram based on the Cox regression model which incorporating variables associated with overall survival (OS) and disease-specific survival (DSS). The novel nomogram model showed the best performance compared with 8th American Joint Committee of Cancer pathological staging schemes of esophagus cancer and gastric cancer. The time-receiver operating characteristic curve of the novel nomogram showed an excellent predictive value in terms of 5-year OS [0.665 (0.626-0.704)] and 5-year DSS [0.675 (0.636-0.713)]. Finally, a friendly online web application was developed for clinical use.
Citation	Zhang J, Liu H, Yu H, Xu WX. Development of a novel staging classification for Siewert II adenocarcinoma of the esophagogastric junction after neoadjuvant chemotherapy. World J Gastrointest Oncol 2024; In press

Received	2023-10-21 09:03
Peer-Review Started	2023-10-21 09:04
To Make the First Decision
Return for Revision	2023-12-31 07:16
Revised	2024-03-09 09:12
Second Decision	2024-04-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-15 06:59
Articles in Press	2024-04-15 06:59
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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