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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 89428
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Clinical Trials Study
Article Title Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers
Manuscript Source Unsolicited Manuscript
All Author List Zhe-Han Bao, Can Hu, Yan-Qiang Zhang, Peng-Cheng Yu, Yi Wang, Zhi-Yuan Xu, Huan-Ying Fu and Xiang-Dong Cheng
Funding Agency and Grant Number
Corresponding Author Xiang-Dong Cheng, MD, Dean, Full Professor, Surgeon, Department of Gastric Surgery, Zhejiang Cancer Hospital, No. 1 Mid-level East Road, Hangzhou 310004, Zhejiang Province, China. chengxd@zjcc.org.cn
Key Words Neoadjuvant therapy; Immunotherapy; Gastric cancer; Borrmann type; Tumor regression grade
Core Tip Borrmann type III and IV gastric cancers (GCs) generally have a poor prognosis. JCOG0501 failed to demonstrate the efficacy of a preoperative neoadjuvant chemotherapy regimen (S-1 plus cisplatin) in patients with type IV or large type III GC. For these patients, we explored the possibility of chemotherapy combined with immunotherapy. The results showed that programmed cell death 1 inhibitors combined with oxaliplatin and S-1 significantly increased Borrmann III. Tumor regression rate during neoadjuvant therapy in patients with type II and type IV GC. At the same time, chemotherapy side effects and surgical complications did not increase.
Citation Bao ZH, Cheng XD, Hu C, Zhang YQ, Yu PC, Wang Y, Fu HY, Xu ZY. Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers. World J Gastrointest Oncol 2024; In press
2023-10-31 10:11
Peer-Review Started
2023-10-31 10:12
To Make the First Decision
Return for Revision
2023-11-26 12:54
2023-12-26 13:50
Second Decision
2024-02-07 03:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-02-07 06:27
Articles in Press
2024-02-07 06:27
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ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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