Publication Name	World Journal of Gastroenterology
Manuscript ID	89778
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
Manuscript Source	Unsolicited Manuscript
All Author List	Zhan-Xue Zhao, Shuai Li and Lin-Xun Liu
Funding Agency and Grant Number	Funding Agency Grant Number Health Commission of Qinghai Province 2021-wjzdx-18
Corresponding Author	Lin-Xun Liu, MD, Chief Physician, Department of General Surgery, Qinghai Provincial People's Hospital, No. 2 Gonghe Road, Chengdong District, Xining 810007, Qinghai Province, China. 147599835@qq.com
Key Words	Thymoquinone; Pancreatic cancer; Hypoxia-inducible factor-1α; PI3K/AKT/mTOR; HSP90
Core Tip	Thymoquinone (TQ) could significantly inhibit the proliferative activity, invasion and migration ability and promote the apoptosis of pancreatic cancer (PC) cells. TQ could inhibit hypoxia-inducible factor-1α (HIF-1α) expression in PC cells. The mechanism of TQ on HIF-1α protein expression in PC cells was to promote the ubiquitination degradation of HIF-1α protein by inhibiting the interaction between HIF-1α and HSP90 and reduce the initial expression of HIF-1α protein by inhibiting the PI3K/AKT/mTOR pathway.
Citation	Zhao ZX, Li S, Liu LX. Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways. World J Gastroenterol 2024; In press

Received	2023-11-12 16:12
Peer-Review Started	2023-11-12 16:13
To Make the First Decision
Return for Revision	2024-01-05 08:21
Revised	2024-04-14 02:37
Second Decision	2024-05-08 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-08 04:41
Articles in Press	2024-05-08 04:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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