Publication Name	World Journal of Clinical Cases
Manuscript ID	90120
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Intestinal flora: New perspective of type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Liu, Jun Chang and Li-Ding Bai
Funding Agency and Grant Number
Corresponding Author	Jun Chang, MD, PhD, Researcher, NA, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Xiqing District, Tianjin 300381, China, Tianjin 300381, China. cj2020_91@163.com
Key Words	Microbial metabolites; Intestinal flora; Probiotics; Insulin resistance; Type 2 diabetes
Core Tip	With the global prevalence of diabetes continuing to rise, China faces a particularly high burden, with diabetes and its complications affecting up to 10% of the population. Type 2 diabetes mellitus (T2DM) constitutes over 90% of these cases. While insulin remains the primary treatment for T2DM, its efficacy is limited in addressing the chronic, progressive, low-grade inflammatory, and the simple reduction of exogenous blood glucose can no longer meet the control of diabetes and its complications, nature of the disease. Consequently, there is an urgent need to identify safe and effective new therapeutic avenues. This letter corroborates the significance of intestinal flora in T2DM, as asserted by Li and Guo. It briefly outlines the role of intestinal flora in T2DM through insights from both animal experiments and clinical studies. Additionally, it discusses the potential clinical applications and challenges associated with targeting intestinal flora as therapeutic targets.
Citation	Liu Y, Chang J, Bai LD. Intestinal flora: New perspective of type 2 diabetes. World J Clin Cases 2024; 12(11): 1996-1999

Received	2023-11-23 15:39
Peer-Review Started	2023-11-23 15:40
To Make the First Decision
Return for Revision	2024-02-06 20:58
Revised	2024-02-19 14:20
Second Decision	2024-03-28 06:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-28 08:05
Articles in Press	2024-03-28 08:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-01 07:12

ISSN	2307-8960 (online)
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