Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90319
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor
Manuscript Source	Invited Manuscript
All Author List	Jing Zhou, Mei-Ying Zhang, Ai-Ai Gao, Cheng Zhu, Tao He, James G Herman and Ming-Zhou Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2018YFA0208902 National Science Foundation of China U160428,182272632,81672318 Beijing Science Foundation of China 7171008 Youth Innovation Science Foundation of Chinese PLA general hospital 22QNCZ027
Corresponding Author	Ming-Zhou Guo, MD, PhD, Professor, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. guomingzhou@301hospital.org
Key Words	Schlafen-11; Esophageal squamous cell carcinoma; DNA methylation; Synthetic lethality; AZD0156
Core Tip	Targeting DNA damage repair (DDR) is a novel strategy for cancer therapy. Epigenetic-based synthetic lethality studies have been conducted recently. Schlafen-11 (SLFN11) has been reported to sensitize cancer cells by involving DDR. However, the detailed regulatory network in DDR remains controversial. This study explored the mechanism of SLFN11 in DDR, and further investigated the synthetic lethal efficiency of epigenetic silencing SLFN11 and ATM inhibitor. The results demonstrated that SLFN11 activated non-homologous end-joining and ATR/CHK1, while inhibiting the ATM/CHK2 signaling pathway. Epigenetic silencing SLFN11 sensitized esophageal cancer cells to ATM inhibitor both in vitro and in vivo.
Citation	Zhou J, Zhang MY, Gao AA, Zhu C, He T, Herman JG, Guo MZ. Epigenetic silencing Schlafen-11 sensitizes esophageal cancer to ATM inhibitor. World J Gastrointest Oncol 2024; 16(5): 2060-2073

Received	2023-11-30 03:32
Peer-Review Started	2023-11-30 03:32
To Make the First Decision
Return for Revision	2024-02-20 01:53
Revised	2024-02-26 15:07
Second Decision	2024-04-01 06:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-01 08:35
Articles in Press	2024-04-01 08:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-23 02:16

ISSN	1948-5204 (online)
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