Publication Name	World Journal of Stem Cells
Manuscript ID	90321
Country	Japan

Category	Surgery
Manuscript Type	Basic Study
Article Title	Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Shuai Zhang, Chuan Lu, Sheng Zheng and Guang Hong
Funding Agency and Grant Number
Corresponding Author	Guang Hong, DDS, MD, PhD, N/A, Division for International Collaborative and Innovative Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan. hong.guang.d6@tohoku.ac.jp
Key Words	Hydrogel; Bone marrow mesenchymal stem cells; Macrophage polarization; Angiogenesis; Bone regeneration
Core Tip	We adopted a new method to enhance tissue repair and promote bone regeneration through hydrogels loaded with mesenchymal stem cell (MSC) exosomes. This experiment demonstrated that bone marrow-derived MSC (BMSC)-derived exosome (BMSC-exo) hydrogel significantly promoted the proliferation, migration and osteogenesis of mouse osteoblast progenitor cells, and at the same time enhanced the M2 polarization of macrophages in bone marrow, thus translating into accelerated fracture healing and angiogenesis in vivo. In addition, BMSC-exo hydrogels successfully enhance the strength and toughness of regenerated bone, with higher maximum load, stiffness and damage absorption energy.
Citation	<p>Zhang S, Lu C, Zheng S, Hong G. Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis. <i>World J Stem Cells</i> 2024; 16(5): 499-511</p>

Received	2023-11-30 03:01
Peer-Review Started	2023-11-30 03:01
To Make the First Decision
Return for Revision	2023-12-21 21:49
Revised	2024-01-17 08:13
Second Decision	2024-03-04 02:54
Accepted by Journal Editor-in-Chief	2024-03-09 02:13
Accepted by Company Editor-in-Chief	2024-04-02 03:20
Articles in Press	2024-04-02 03:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-13 09:18

ISSN	1948-0210 (online)
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