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Publication Name World Journal of Stem Cells
Manuscript ID 90321
Country Japan
Category Surgery
Manuscript Type Basic Study
Article Title Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis
Manuscript Source Unsolicited Manuscript
All Author List Shuai Zhang, Chuan Lu, Sheng Zheng and Guang Hong
Funding Agency and Grant Number
Corresponding Author Guang Hong, DDS, MD, PhD, N/A, Division for International Collaborative and Innovative Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan. hong.guang.d6@tohoku.ac.jp
Key Words Hydrogel; Bone marrow mesenchymal stem cells; Macrophage polarization; Angiogenesis; Bone regeneration
Core Tip We adopted a new method to enhance tissue repair and promote bone regeneration through hydrogels loaded with mesenchymal stem cell (MSC) exosomes. This experiment demonstrated that bone marrow-derived MSC (BMSC)-derived exosome (BMSC-exo) hydrogel significantly promoted the proliferation, migration and osteogenesis of mouse osteoblast progenitor cells, and at the same time enhanced the M2 polarization of macrophages in bone marrow, thus translating into accelerated fracture healing and angiogenesis in vivo. In addition, BMSC-exo hydrogels successfully enhance the strength and toughness of regenerated bone, with higher maximum load, stiffness and damage absorption energy.
Citation Zhang S, Lu C, Zheng S, Hong G. Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis. World J Stem Cells 2024; In press
Received
2023-11-30 03:01
Peer-Review Started
2023-11-30 03:01
To Make the First Decision
Return for Revision
2023-12-21 21:49
Revised
2024-01-17 08:13
Second Decision
2024-03-04 02:54
Accepted by Journal Editor-in-Chief
2024-03-09 02:13
Accepted by Company Editor-in-Chief
2024-04-02 03:20
Articles in Press
2024-04-02 03:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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