Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90598
Country	China

Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Jie Xu, Ya-Chang Huo, Qi-Tai Zhao, Jin-Yan Liu, Yi-Jun Tian, Lei-Lei Yang and Yi Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Henan Province Medical Science and Technology Research Provincial and Ministry Co-constructed Projects SBGJ202101010 Major Public Welfare Projects in Henan Province 201300310400 Joint Construction Project of Henan Medical Science and Technology Research Plan LHGJ20220050 Major Science and Technology Project of Henan Province 221100310100
Corresponding Author	Yi Zhang, MD, PhD, Chief Physician, Full Professor, Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. yizhang@zzu.edu.cn
Key Words	Colorectal cancer; Metabolic reprogramming; Metastasis; Nicotinamide adenine dinucleotide phosphate oxidase 4; Mitogen-activated protein kinase signaling
Core Tip	We first identified three clusters with different survival status based on dysregulated metabolic genes in colorectal cancer (CRC). In addition, based on differentially expressed survival-related metabolic genes, we constructed and validated a prediction model using different cohorts. Among these genes, nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling pathway to promote cancer metastasis, whereas trametinib (a MEK1/2 inhibitor) treatment reversed this effect. Our study analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis, suggesting that NOX4 could be a new therapeutic target and modulating the response to clinical therapy.
Citation	Xu YJ, Huo YC, Zhao QT, Liu JY, Tian YJ, Yang LL, Zhang Y. NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer. World J Gastrointest Oncol 2024; 16(4): 1421-1436

Received	2023-12-08 13:30
Peer-Review Started	2023-12-08 13:30
To Make the First Decision
Return for Revision	2023-12-22 11:45
Revised	2024-01-04 13:56
Second Decision	2024-02-07 02:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-07 06:37
Articles in Press	2024-02-07 06:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-07 03:40

ISSN	1948-5204 (online)
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