Publication Name	World Journal of Virology
Manuscript ID	90668
Country	Congo

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Randomized Clinical Trial
Article Title	Hydroxychloroquine-azithromycin, doubase C, and QTc prolongation in congolese patients with COVID-19: Myth or reality?
Manuscript Source	Unsolicited Manuscript
All Author List	Brady Madioko Makanzu, Jean-Robert Makulo, Madone Ndona Mandina, Dimosi Roger Wumba, Murielle Mashi Longokolo, Hippolyte Situakibanza, Ossam Odio, Donat Sonzi Mangala, Constantin Mihigo Bashengezi, Benjamin Kabwe Mwilambwe, Gilbert Kabanda Kurhenga, Benjamin Longo-Mbenza and Roger Mwimba Mbungu
Funding Agency and Grant Number
Corresponding Author	Brady Madioko Makanzu, MD, Doctor, Department of Cardiology, Kinshasa University Hospital, Kinshasa, DR Congo , Kinshasa University Hospital, Kimwenza Road, Lemba Municipality, Kinshasa City, Kinshasa 11, Congo. bmaknzu@gmail.com
Key Words	QTc prolongation; COVID-19; Doubase C; HCQ-AZT; Sub-Saharan Africa
Core Tip	During the coronavirus disease 2019 (COVID-19) pandemic, western studies have shown the ineffectiveness and cardiotoxic effects of hydroxychloriquine and azithromycin (HCQ-AZI). In Africa, the heart toxicity of HCQ-AZI is little reported by cardiologists, and some african countries used these two molecules to treat COVID-19 patients. In the present study, we have evaluated the occurrence of prolongation of the QTc interval and torsade de pointes torsade in Congolese COVID-19 patients who received HCQ-AZI compared to Doubase C, a herbal medicine with broad-spectrum antiviral activity.
Citation	Madioko Makanzu B, Makulo JR, Ndona Mandina M, Wumba DR, Mashi Longokolo M, Situakibanza H, Odio O, Sonzi Mangala D, Mihigo Bashengezi C, Kabwe Mwilambwe B, Kabanda Kurhenga G, Longo-Mbenza B, Mwimba Mbungu R. Hydroxychloroquine-azithromycin, doubase C, and QTc prolongation in congolese patients with COVID-19: Myth or reality? World J Virol 2024; In press

Received	2023-12-18 15:42
Peer-Review Started	2023-12-10 18:58
To Make the First Decision
Return for Revision	2024-03-10 02:11
Revised	2024-04-05 19:57
Second Decision	2024-04-19 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-19 07:08
Articles in Press	2024-04-19 07:08
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ISSN	2220-3249 (online)
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