Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90680
Country	Colombia

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Pancreatic neuroendocrine tumors: Are tumors smaller than 2 cm truly indolent?
Manuscript Source	Invited Manuscript
All Author List	Sergio Hoyos, Pablo Posada-Moreno, Natalia Guzman-Arango, Romario Chanci-Drago, Jaime Chavez, Alvaro Andrés-Duarte and Santiago Salazar-Ochoa
Funding Agency and Grant Number
Corresponding Author	Sergio Hoyos, MD, MSc, Adjunct Professor, Chief Doctor, Chief Physician, Hepatobilary and Liver Transplant Unit, Hospital Pablo Tobon Uribe and Gastrohepathology Group Universidad de Antioquia, Calle 70 No. 52-21, Medellín 050034, Antioquia, Colombia. sergiohoyosd@yahoo.es
Key Words	Neuroendocrine tumor; Pancreatic neoplasm; Pancreas; Pancreatic neuroendocrine neoplasm; Pancreatic neuroendocrine tumors
Core Tip	Pancreatic neuroendocrine tumors (PNETs) are relatively uncommon but represent the second most frequent pancreatic neoplasm. This study, conducted in Colombia, challenges conventional size-based survival expectations for PNETs and advocates a surgical approach, even for tumors smaller than 2 cm. The findings underscore the importance of considering histological traits like lymphovascular and neural invasion, high mitotic index, and a Ki67 proliferation index exceeding 3%. These characteristics, traditionally associated with larger tumors and higher mortality rates, were also identified in a significant fraction of smaller tumors. More comprehensive studies are necessary to redefine clinical approaches and guidelines for managing PNETs.
Citation	Hoyos S, Posada-Moreno P, Guzman-Arango N, Chanci-Drago R, Chavez J, Andrés-Duarte A, Salazar-Ochoa S. Pancreatic neuroendocrine tumors: Are tumors smaller than 2 cm truly indolent? World J Gastrointest Oncol 2024; 16(5): 1756-1762

Received	2023-12-20 20:47
Peer-Review Started	2023-12-20 20:47
To Make the First Decision
Return for Revision	2024-01-10 08:41
Revised	2024-02-07 02:19
Second Decision	2024-03-25 01:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-25 02:26
Articles in Press	2024-03-25 02:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-22 00:36

ISSN	1948-5204 (online)
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