Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	90986
Country	Italy

Category	Surgery
Manuscript Type	Editorial
Article Title	Indocyanine green: The guide to safer and more effective surgery
Manuscript Source	Invited Manuscript
All Author List	Pietro Fransvea, Maria Michela Chiarello, Valeria Fico, Maria Cariati and Giuseppe Brisinda
Funding Agency and Grant Number
Corresponding Author	Giuseppe Brisinda, MD, Professor, Surgeon, Department of Abdominal and Endocrine Metabolic Medical and Surgical Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, No. 8 Largo Agostino Gemelli, Rome 00168, Italy. gbrisin@tin.it
Key Words	Indocyanine green; Colorectal surgery; Fluorescence-guided surgery; Gastrointestinal surgery; Hepato-biliary surgery; Pancreatic surgery; Surgical oncology
Core Tip	Indocyanine green is a sterile, anionic, water-soluble molecule, which was approved for clinical use in 1959 by the Food and Drug Administration. After intravenous injection, indocyanine green rapidly bounds to plasma lipoproteins. When injected outside blood vessels (e.g., into the normal tissue close to tumors), indocyanine green binds to proteins, reaching the nearest lymph node usually within 15 min. The intraoperative usage of indocyanine green has become common in a variety of surgical specialties and transplant surgery. By observing the signal using a fluorescence imaging video system, surgeons can visualize and assess organ perfusion intraoperatively while making adjustments in real-time.
Citation	Fransvea P, Chiarello MM, Fico V, Cariati M, Brisinda G. Indocyanine green: The guide to safer and more effective surgery. World J Gastrointest Surg 2024; 16(3): 641-649

Received	2023-12-19 08:41
Peer-Review Started	2023-12-19 08:41
To Make the First Decision
Return for Revision	2024-01-15 09:39
Revised	2024-01-15 13:06
Second Decision	2024-02-08 04:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-02-08 07:29
Articles in Press	2024-02-08 07:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-14 01:48

ISSN	1948-9366 (online)
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