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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 91027
Country China
Category Medicine, Research & Experimental
Manuscript Type Observational Study
Article Title Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population
Manuscript Source Unsolicited Manuscript
All Author List Wen-Feng Luo, Yu-Ting Jiao, Xiao-Ling Lin, Ying Zhao, Sheng-Bo Wang, Jian Shen, Jie Deng, Yu-Feng Ye, Ze-Ping Han, Fang-Mei Xie, Jin-Hua He and Yu Wan
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Program of Panyu Central Hospital PY-2023-003
Science and Technology Program of Panyu 2020-Z04-054
Science and Technology Project of the Guangzhou Health Commission 20211A011114
Science and Technology Program of Guangzhou 202002020023
General University Youth Innovative Talent Project of Guangdong Province 2022KQNCX281
Guangdong Provincial Key Field Special Project for Ordinary Colleges and Universities 2023ZDZX2097
Foshan Engineering Technology Research Center for Prepared Food Processing and Quality Evaluation 2022-KJZX113
Corresponding Author Yu Wan, Doctor, Doctor, Digestive Disease Center, Guangzhou Panyu Central Hospital, Guangzhou 511400, Guangdong Province, China. wanyur@vip.163.com
Key Words Colorectal cancer; Syndecan-2; DNA methylation; Chinese population
Core Tip A high-risk Chinese cohort composed of 1130 individuals 40-79 years of age was selected for evaluation using the fecal syndecan-2 methylation (mSDC2) test. Sensitivity and specificity to colorectal cancer (CRC), advanced adenoma and advanced colorectal neoplasia were quantified. High-risk factors for the incidence of colorectal lesions were analyzed; a logistic regression model was subsequently constructed to better reflect the efficacy of fecal mSDC2 testing. The results of this CRC screening study revealed that offering patients a combination of fecal mSDC2 testing and colonoscopy is ideal for facilitating early detection of CRC among a high-risk Chinese population.
Citation Luo WF, Jiao YT, Lin XL, Zhao Y, Wang SB, Shen J, Deng J, Ye YF, Han ZP, Xie FM, He JH, Wan Y. Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population. World J Gastrointest Oncol 2024; 16(4): 1361-1373
Received
2023-12-21 00:31
Peer-Review Started
2023-12-21 01:27
To Make the First Decision
Return for Revision
2023-12-31 01:35
Revised
2024-01-12 05:15
Second Decision
2024-02-07 02:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-02-07 06:49
Articles in Press
2024-02-07 06:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-03-07 03:35
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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