Publication Name	World Journal of Gastroenterology
Manuscript ID	91102
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
Manuscript Source	Invited Manuscript
All Author List	Antonietta Gerarda Gravina, Iacopo Panarese, Maria Consiglia Trotta, Michele D'Amico, Raffaele Pellegrino, Franca Ferraraccio, Marilena Galdiero, Roberto Alfano, Paolo Grieco and Alessandro Federico
Funding Agency and Grant Number
Corresponding Author	Raffaele Pellegrino, MD, N/A, Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. de Crecchio, Naples 80138, Italy. raffaele.pellegrino@unicampania.it
Key Words	Melanocortin 3 receptor; Melanocortin 5 receptor; Ulcerative colitis; Crohn's disease; Inflammatory bowel disease
Core Tip	This study sought to examine the expression levels of Melanocortin 3 and 5 receptors (MC3R and MC5R) in the colons of individuals diagnosed with Crohn's disease and ulcerative colitis. Analysis of tissue samples obtained from both inflamed and non-inflamed sections of the colon revealed a notable increase in the expression of both receptors within inflamed regions compared to non-inflamed areas, with the extent of expression suggesting a potential association with the severity of disease activity. These findings imply that MC3R and MC5R may serve as potential targets for pharmacological interventions in the context of inflammatory bowel diseases.
Citation	Gravina AG, Panarese I, Trotta MC, D'Amico M, Pellegrino R, Ferraraccio F, Galdiero M, Alfano R, Grieco P, Federico A. Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity? World J Gastroenterol 2024; 30(9): 1132-1142

Received	2023-12-21 16:49
Peer-Review Started	2023-12-21 16:49
To Make the First Decision
Return for Revision	2024-01-13 08:21
Revised	2024-01-15 21:06
Second Decision	2024-02-08 04:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-08 07:31
Articles in Press	2024-02-08 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-26 05:54

ISSN	1007-9327 (print) and 2219-2840 (online)
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