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Publication Name World Journal of Gastroenterology
Manuscript ID 91102
Country Italy
Category Gastroenterology & Hepatology
Manuscript Type Clinical Trials Study
Article Title Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
Manuscript Source Invited Manuscript
All Author List Antonietta Gerarda Gravina, Iacopo Panarese, Maria Consiglia Trotta, Michele D'Amico, Raffaele Pellegrino, Franca Ferraraccio, Marilena Galdiero, Roberto Alfano, Paolo Grieco and Alessandro Federico
Funding Agency and Grant Number
Corresponding Author Raffaele Pellegrino, MD, N/A, Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. de Crecchio, Naples 80138, Italy. raffaele.pellegrino@unicampania.it
Key Words Melanocortin 3 receptor; Melanocortin 5 receptor; Ulcerative colitis; Crohn's disease; Inflammatory bowel disease
Core Tip This study sought to examine the expression levels of Melanocortin 3 and 5 receptors (MC3R and MC5R) in the colons of individuals diagnosed with Crohn's disease and ulcerative colitis. Analysis of tissue samples obtained from both inflamed and non-inflamed sections of the colon revealed a notable increase in the expression of both receptors within inflamed regions compared to non-inflamed areas, with the extent of expression suggesting a potential association with the severity of disease activity. These findings imply that MC3R and MC5R may serve as potential targets for pharmacological interventions in the context of inflammatory bowel diseases.
Citation Gravina AG, Panarese I, Trotta MC, D'Amico M, Pellegrino R, Ferraraccio F, Galdiero M, Alfano R, Grieco P, Federico A. Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity? World J Gastroenterol 2024; 30(9): 1132-1142
2023-12-21 16:49
Peer-Review Started
2023-12-21 16:49
To Make the First Decision
Return for Revision
2024-01-13 08:21
2024-01-15 21:06
Second Decision
2024-02-08 04:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-02-08 07:31
Articles in Press
2024-02-08 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-02-26 05:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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