Publication Name	World Journal of Psychiatry
Manuscript ID	91133
Country	China

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Peng Hou, Xiang-Qin Qin, Wei-Wei Hou, Yun-Yi Han, Qi-Jing Bo, Fang Dong, Fu-Chun Zhou, Xian-Bin Li and Chuan-Yue Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 81971250 Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZLRK202335 Early Psychosis Cohort Program of Beijing Anding Hospital ADDL-03
Corresponding Author	Chuan-Yue Wang, MD, PhD, Professor, Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, Dewai Avenue, Xicheng District, Beijing 100088, China. wang_cy@ccmu.edu.cn
Key Words	Catechol-O-methyltransferase Val/Met polymorphism; Cognitive reserve; Crystallized intelligence; Negative symptoms; Schizophrenia
Core Tip	Cognitive reserve (CR) and the catechol-O-methyltransferase (COMT) Val/Met polymorphism are reportedly linked to negative symptoms, which are a core clinical manifestation of schizophrenia. However, the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is unclear. In this study, COMT Met-carriers exhibited fewer negative symptoms than Val homozygotes. Information and similarities showed interaction effects with the COMT genotype in terms of negative symptoms. This preliminary study shows that the association between negative symptoms and CR may be under the regulation of the COMT genotype in schizophrenia.
Citation	Hou WP, Qin XQ, Hou WW, Han YY, Bo QJ, Dong F, Zhou FC, Li XB, Wang CY. Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia. World J Psychiatry 2024; In press

Received	2023-12-22 15:01
Peer-Review Started	2023-12-22 15:01
To Make the First Decision
Return for Revision	2024-03-31 04:56
Revised	2024-04-09 15:44
Second Decision	2024-04-22 02:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-22 06:40
Articles in Press	2024-04-22 06:40
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ISSN	2220-3206 (online)
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