Publication Name	World Journal of Stem Cells
Manuscript ID	91174
Country	Italy

Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments
Manuscript Source	Invited Manuscript
All Author List	Edoardo Agosti, Marco Zeppieri, Mattia Ghidoni, Tamara Ius, Alessandro Tel, Marco Maria Fontanella and Pier Paolo Panciani
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, MD, PhD, Doctor, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Glioma stem cells; Chemoresistance; Radioresistance; Molecular pathways; Targeted therapies; Systematic review
Core Tip	The challenge of treating gliomas persists despite advancements in chemotherapy and radiotherapy, with glioma stem cells (GSCs) contributing to resistance and tumor heterogeneity. This systematic literature review, covering 66 studies, underscores the intricate role of GSCs in therapeutic resistance, particularly highlighting their involvement in DNA repair mechanisms and dynamic cellular state transitions. Targeted therapies face challenges due to GSCs’ high plasticity, and the review emphasizes the need for precision treatments that account for GSC population heterogeneity and the tumor microenvironment’s dynamic nature. Versatile therapeutic agents, including RNA inhibitor/short hairpin RNA, inhibitors (e.g., LY294002, NVP-BEZ235), and monoclonal antibodies (e.g., cetuximab), demonstrate efficacy in overcoming GSC-mediated resistance. Notably, the most common effect on the chemo- and radiotherapy response is a reduction in temozolomide resistance, highlighting the potential for improved outcomes by disrupting GSC-mediated resistance mechanisms in glioblastoma patients.
Citation	Agosti E, Zeppieri M, Ghidoni M, Ius T, Tel A, Fontanella MM, Panciani PP. Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments. World J Stem Cells 2024; In press

Received	2023-12-23 17:02
Peer-Review Started	2023-12-23 17:02
To Make the First Decision
Return for Revision	2024-03-06 03:43
Revised	2024-03-06 12:43
Second Decision	2024-04-07 00:16
Accepted by Journal Editor-in-Chief	2024-04-13 13:08
Accepted by Company Editor-in-Chief	2024-04-19 06:41
Articles in Press	2024-04-19 06:41
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ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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